P4HB Products
(Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
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This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].
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Featured P4HB Categories
P4HB Antibodies
High quality antibodies with extensive validation data.
P4HB ELISA Kits
Reliable ELISA kits for a wide range of species.
P4HB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended P4HB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, ICC, IHC (p), IEM
Validations
- (6)
Cat. No.
ABIN2855054
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, IF
Validations
- (6)
Cat. No.
ABIN950024
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, FACS
Validations
- (6)
Cat. No.
ABIN6134876
Quantity
100 μL
Datasheet
Datasheet
Recommended P4HB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969624
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958836
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1116747
Quantity
96 tests
Datasheet
Datasheet
Recommended P4HB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313838
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124599
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320210
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our P4HB products
: "Radical Stress Is More Cytotoxic in the Nucleus than in Other Organelles." in: International journal of molecular sciences, Vol. 20, Issue 17, (2020) (PubMed).: "Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas." in: Cell death & disease, Vol. 10, Issue 2, pp. 143, (2020) (PubMed).
: "A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome." in: Cell chemical biology, Vol. 25, Issue 5, pp. 634-643.e4, (2019) (PubMed).
: "LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel." in: International journal of cardiology, Vol. 275, pp. 120-128, (2019) (PubMed).
: "Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum. ..." in: Cell, Vol. 176, Issue 6, pp. 1461-1476.e23, (2019) (PubMed).
: "Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes." in: Redox biology, Vol. 22, pp. 101142, (2019) (PubMed).
: "GLUT10-Lacking in Arterial Tortuosity Syndrome-Is Localized to the Endoplasmic Reticulum of Human Fibroblasts." in: International journal of molecular sciences, Vol. 18, Issue 8, (2018) (PubMed).
: "Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells." in: Oncotarget, Vol. 8, Issue 22, pp. 35592-35608, (2017) (PubMed).
: "Myogenic potential of human alveolar mucosa derived cells." in: Cell cycle (Georgetown, Tex.), Vol. 16, Issue 6, pp. 545-555, (2017) (PubMed).
: "Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects." in: Biochimica et biophysica acta, Vol. 1861, Issue 11, pp. 1623-1633, (2016) (PubMed).
Synonyms and alternative names related to P4HB
prolyl 4-hydroxylase subunit beta (P4HB), protein disulfide isomerase family A member 2 (PDIA2), prolyl 4-hydroxylase, beta polypeptide (P4hb), prolyl 4-hydroxylase subunit beta (P4hb), prolyl 4-hydroxylase, beta polypeptide (P4HB), protein disulfide isomerase family A member 2 L homeolog (pdia2.L), protein disulfide isomerase associated 2 (Pdia2), prolyl 4-hydroxylase subunit beta L homeolog (p4hb.L), protein disulfide-isomerase (LOC8281065), 1810041F13Rik, AI661267, DSI, ERBA2L, ERp59, GIT, P4Hbeta, p55, p58, PDA2, PDI, pdi, PDIA1, Pdia1, PDIP, Pdip, Pdipl, PDIR, PHDB, PO4DB, PO4HB, PROHB, Thbp, XPDIpProtein level used designations for P4HB
- cellular thyroid hormone-binding protein
- collagen prolyl 4-hydroxylase beta
- glutathione-insulin transhydrogenase
- p55
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
- prolyl 4-hydroxylase subunit beta
- protein disulfide isomerase family A, member 1
- protein disulfide isomerase-associated 1
- protein disulfide isomerase/oxidoreductase
- protein disulfide-isomerase
- protocollagen hydroxylase
- thyroid hormone-binding protein p55
- Rho GDP dissociation inhibitor gamma
- pancreas-specific protein disulfide isomerase
- pancreatic protein disulfide isomerase
- protein disulfide isomerase A2
- protein disulfide isomerase, pancreatic
- protein disulfide isomerase-associated 2
- protein disulfide-isomerase A2
- ER protein 59
- endoplasmic reticulum resident protein 59
- protein disulfide isomerase
- Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)
- PDI (E.C.5.3.4.1)
- cellular thyroid hormone binding protein
- prolyl 4-hydroxylase beta polypeptide
- prolyl 4-hydroxylase, beta subunit
- Cellular thyroid hormone-binding protein
- Prolyl 4-hydroxylase subunit beta
- multifunctional thyroid hormone binding protein
- PDI
- protein disulfide isomerase (pancreas) like
- R-cognin
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1)
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)
- retina cognin
- protein disulphide isomerase PDI
- p58
- prolyl 4-hydroxylase, beta polypeptide
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