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P4HB Products

(Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

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This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].

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Featured P4HB Categories

P4HB Antibodies

High quality antibodies with extensive validation data.

P4HB ELISA Kits

Reliable ELISA kits for a wide range of species.

P4HB Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended P4HB Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, ICC, IHC (p), IEM
Validations
  • (6)
Cat. No. ABIN2855054
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP, IF
Validations
  • (6)
Cat. No. ABIN950024
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, FACS
Validations
  • (6)
Cat. No. ABIN6134876
Quantity 100 μL
Datasheet Datasheet

Recommended P4HB ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969624
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958836
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1116747
Quantity 96 tests
Datasheet Datasheet

Recommended P4HB Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313838
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124599
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320210
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our P4HB products

Paardekooper, van Vroonhoven, Ter Beest, van den Bogaart: "Radical Stress Is More Cytotoxic in the Nucleus than in Other Organelles." in: International journal of molecular sciences, Vol. 20, Issue 17, (2020) (PubMed).

De Bessa, Pagano, Moretti, Oliveira, Mendonça, Kovacic, Laurindo: "Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas." in: Cell death & disease, Vol. 10, Issue 2, pp. 143, (2020) (PubMed).

Omachi, Kamura, Teramoto, Kojima, Yokota, Kaseda, Kuwazuru, Fukuda, Koyama, Matsuyama, Motomura, Shuto, Suico, Kai: "A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome." in: Cell chemical biology, Vol. 25, Issue 5, pp. 634-643.e4, (2019) (PubMed).

Liang, Wu, Zhou, Chen, Liu, Xie, Huang, Zhang, Liu, Zhu, Li, Chen: "LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel." in: International journal of cardiology, Vol. 275, pp. 120-128, (2019) (PubMed).

Subramanian, Capalbo, Iyengar, Rizzo, di Campli, Di Martino, Lo Monte, Beccari, Yerudkar, Del Vecchio, Glielmo, Turacchio, Pirozzi, Kim, Henklein, Cancino, Parashuraman, Diviani, Fanelli, Sallese et al.: "Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum. ..." in: Cell, Vol. 176, Issue 6, pp. 1461-1476.e23, (2019) (PubMed).

Oliveira, Garcia-Rosa, Sachetto, Moretti, Debbas, De Bessa, Silva, Pereira, Martins-de-Souza, Santoro, Laurindo: "Protein disulfide isomerase plasma levels in healthy humans reveal proteomic signatures involved in contrasting endothelial phenotypes." in: Redox biology, Vol. 22, pp. 101142, (2019) (PubMed).

Gamberucci, Marcolongo, Németh, Zoppi, Szarka, Chiarelli, Hegedűs, Ritelli, Carini, Willaert, Callewaert, Coucke, Benedetti, Margittai, Fulceri, Bánhegyi, Colombi: "GLUT10-Lacking in Arterial Tortuosity Syndrome-Is Localized to the Endoplasmic Reticulum of Human Fibroblasts." in: International journal of molecular sciences, Vol. 18, Issue 8, (2018) (PubMed).

Limoge, Safina, Beattie, Kapus, Truskinovsky, Bakin: "Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells." in: Oncotarget, Vol. 8, Issue 22, pp. 35592-35608, (2017) (PubMed).

Zorin, Pulin, Eremin, Korsakov, Zorina, Khromova, Sokova, Kotenko, Kopnin: "Myogenic potential of human alveolar mucosa derived cells." in: Cell cycle (Georgetown, Tex.), Vol. 16, Issue 6, pp. 545-555, (2017) (PubMed).

Walsh, Di Leo, Okur, Tarugi, Hussain: "Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects." in: Biochimica et biophysica acta, Vol. 1861, Issue 11, pp. 1623-1633, (2016) (PubMed).

Synonyms and alternative names related to P4HB

prolyl 4-hydroxylase subunit beta (P4HB), protein disulfide isomerase family A member 2 (PDIA2), prolyl 4-hydroxylase, beta polypeptide (P4hb), prolyl 4-hydroxylase subunit beta (P4hb), prolyl 4-hydroxylase, beta polypeptide (P4HB), protein disulfide isomerase family A member 2 L homeolog (pdia2.L), protein disulfide isomerase associated 2 (Pdia2), prolyl 4-hydroxylase subunit beta L homeolog (p4hb.L), protein disulfide-isomerase (LOC8281065), 1810041F13Rik, AI661267, DSI, ERBA2L, ERp59, GIT, P4Hbeta, p55, p58, PDA2, PDI, pdi, PDIA1, Pdia1, PDIP, Pdip, Pdipl, PDIR, PHDB, PO4DB, PO4HB, PROHB, Thbp, XPDIp

Protein level used designations for P4HB

  • cellular thyroid hormone-binding protein
  • collagen prolyl 4-hydroxylase beta
  • glutathione-insulin transhydrogenase
  • p55
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
  • prolyl 4-hydroxylase subunit beta
  • protein disulfide isomerase family A, member 1
  • protein disulfide isomerase-associated 1
  • protein disulfide isomerase/oxidoreductase
  • protein disulfide-isomerase
  • protocollagen hydroxylase
  • thyroid hormone-binding protein p55
  • Rho GDP dissociation inhibitor gamma
  • pancreas-specific protein disulfide isomerase
  • pancreatic protein disulfide isomerase
  • protein disulfide isomerase A2
  • protein disulfide isomerase, pancreatic
  • protein disulfide isomerase-associated 2
  • protein disulfide-isomerase A2
  • ER protein 59
  • endoplasmic reticulum resident protein 59
  • protein disulfide isomerase
  • Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)
  • PDI (E.C.5.3.4.1)
  • cellular thyroid hormone binding protein
  • prolyl 4-hydroxylase beta polypeptide
  • prolyl 4-hydroxylase, beta subunit
  • Cellular thyroid hormone-binding protein
  • Prolyl 4-hydroxylase subunit beta
  • multifunctional thyroid hormone binding protein
  • PDI
  • protein disulfide isomerase (pancreas) like
  • R-cognin
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)
  • retina cognin
  • protein disulphide isomerase PDI
  • p58
  • prolyl 4-hydroxylase, beta polypeptide
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