P4HA1 Products
(Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1))
Categories
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured P4HA1 Categories
P4HA1 Antibodies
High quality antibodies with extensive validation data.
P4HA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
P4HA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended P4HA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (7)
Cat. No.
ABIN190847
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7164781
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
- (2)
Cat. No.
ABIN518574
Quantity
50 μg
Datasheet
Datasheet
Recommended P4HA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969620
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969621
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958833
Quantity
96 tests
Datasheet
Datasheet
Recommended P4HA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124598
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313832
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397948
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our P4HA1 products
: "In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes." in: BMC musculoskeletal disorders, Vol. 20, Issue 1, pp. 19, (2019) (PubMed).: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer." in: Journal of molecular medicine (Berlin, Germany), Vol. 92, Issue 2, pp. 151-64, (2014) (PubMed).
: "Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse." in: American journal of physiology. Heart and circulatory physiology, Vol. 307, Issue 5, pp. H773-81, (2014) (PubMed).
: "Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10819-29, (2013) (PubMed).
: "Collagen prolyl hydroxylases are essential for breast cancer metastasis." in: Cancer research, Vol. 73, Issue 11, pp. 3285-96, (2013) (PubMed).
: "BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis." in: The Journal of investigative dermatology, Vol. 132, Issue 8, pp. 2010-8, (2012) (PubMed).
: "Proteomic changes in articular cartilage of human endemic osteoarthritis in China." in: Proteomics, Vol. 11, Issue 14, pp. 2881-90, (2011) (PubMed).
: "Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2." in: Molecular and cellular biology, Vol. 31, Issue 23, pp. 4760-74, (2011) (PubMed).
: "Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7067-78, (2010) (PubMed).
Synonyms and alternative names related to P4HA1
prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ000975), prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ017131), prolyl 4-hydroxylase subunit alpha-1 (Tsp_03346), prolyl 4-hydroxylase subunit alpha-1 (Tsp_03347), prolyl 4-hydroxylase subunit alpha-1 (Tsp_15957), prolyl 4-hydroxylase subunit alpha 1 (P4HA1), procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide (P4ha1), prolyl 4-hydroxylase subunit alpha 1 (P4ha1), AL022634, P4HA, P4ha, PHalphaIProtein level used designations for P4HA1
- prolyl 4-hydroxylase subunit alpha-1
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
- prolyl 4-hydroxylase alpha subunit
- prolyl 4-hydroxylase, alpha I subunit
- 4-PH alpha-1
- procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
- C-P4Halpha(I)
- collagen prolyl 4-hydroxylase alpha(I)
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
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