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P4HA1 Products

(Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1))

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This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

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Featured P4HA1 Categories

P4HA1 Antibodies

High quality antibodies with extensive validation data.

P4HA1 ELISA Kits

Reliable ELISA kits for a wide range of species.

P4HA1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended P4HA1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (7)
Cat. No. ABIN190847
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7164781
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
  • (2)
Cat. No. ABIN518574
Quantity 50 μg
Datasheet Datasheet

Recommended P4HA1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969620
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969621
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958833
Quantity 96 tests
Datasheet Datasheet

Recommended P4HA1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124598
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313832
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397948
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our P4HA1 products

Islam, Fossum, Hansen, Urbarova, Knutsen, Martinez-Zubiaurre: "In vitro chondrogenic potency of surplus chondrocytes from autologous transplantation procedures does not predict short-term clinical outcomes." in: BMC musculoskeletal disorders, Vol. 20, Issue 1, pp. 19, (2019) (PubMed).

Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).

Xiang, Gilkes, Chaturvedi, Luo, Hu, Takano, Liang, Semenza: "Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer." in: Journal of molecular medicine (Berlin, Germany), Vol. 92, Issue 2, pp. 151-64, (2014) (PubMed).

Cowling, Yeo, Kim, Park, Gu, Dalton, Peterson, Greenberg: "Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse." in: American journal of physiology. Heart and circulatory physiology, Vol. 307, Issue 5, pp. H773-81, (2014) (PubMed).

Gilkes, Bajpai, Chaturvedi, Wirtz, Semenza: "Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10819-29, (2013) (PubMed).

Gilkes, Chaturvedi, Bajpai, Wong, Wei, Pitcairn, Hubbi, Wirtz, Semenza: "Collagen prolyl hydroxylases are essential for breast cancer metastasis." in: Cancer research, Vol. 73, Issue 11, pp. 3285-96, (2013) (PubMed).

Ishikura-Kinoshita, Saeki, Tsuji-Naito: "BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis." in: The Journal of investigative dermatology, Vol. 132, Issue 8, pp. 2010-8, (2012) (PubMed).

Ma, Guo, Liu, Liu, Hu, Sun, Yu, Lammi: "Proteomic changes in articular cartilage of human endemic osteoarthritis in China." in: Proteomics, Vol. 11, Issue 14, pp. 2881-90, (2011) (PubMed).

Wu, So, Davis-Dusenbery, Qi, Bloch, Shi, Lagna, Hata: "Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2." in: Molecular and cellular biology, Vol. 31, Issue 23, pp. 4760-74, (2011) (PubMed).

Van Duyn Graham, Sweetwyne, Pallero, Murphy-Ullrich: "Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7067-78, (2010) (PubMed).

Synonyms and alternative names related to P4HA1

prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ000975), prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ017131), prolyl 4-hydroxylase subunit alpha-1 (Tsp_03346), prolyl 4-hydroxylase subunit alpha-1 (Tsp_03347), prolyl 4-hydroxylase subunit alpha-1 (Tsp_15957), prolyl 4-hydroxylase subunit alpha 1 (P4HA1), procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide (P4ha1), prolyl 4-hydroxylase subunit alpha 1 (P4ha1), AL022634, P4HA, P4ha, PHalphaI

Protein level used designations for P4HA1

  • prolyl 4-hydroxylase subunit alpha-1
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
  • prolyl 4-hydroxylase alpha subunit
  • prolyl 4-hydroxylase, alpha I subunit
  • 4-PH alpha-1
  • procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
  • C-P4Halpha(I)
  • collagen prolyl 4-hydroxylase alpha(I)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
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