p130 Products
(Retinoblastoma-Like 2 (p130) (RBL2))
Categories
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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Featured p130 Categories
p130 Antibodies
High quality antibodies with extensive validation data.
p130 ELISA Kits
Reliable ELISA kits for a wide range of species.
p130 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended p130 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (1)
- (3)
Cat. No.
ABIN656158
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, FACS
Validations
- (4)
Cat. No.
ABIN5542553
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IF, IHC
Validations
- (2)
Cat. No.
ABIN7075406
Quantity
100 μL
Datasheet
Datasheet
Recommended p130 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1155325
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1155326
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1155327
Quantity
96 tests
Datasheet
Datasheet
Recommended p130 Proteins
Latest Publications for our p130 products
: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).: "Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells." in: Molecular and cellular biology, Vol. 32, Issue 11, pp. 2065-82, (2012) (PubMed).
: "A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo." in: Oncogene, Vol. 26, Issue 13, pp. 1829-39, (2007) (PubMed).
: "From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway." in: Journal of cellular biochemistry, Vol. 102, Issue 6, pp. 1400-4, (2007) (PubMed).
: "Frequent loss of pRb2/p130 in human ovarian carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 9, pp. 3098-103, (2004) (PubMed).
: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, (2002) (PubMed).
: "The retinoblastoma family: twins or distant cousins?" in: Genome biology, Vol. 3, Issue 9, pp. reviews3012, (2002) (PubMed).
: "p107 and p130: versatile proteins with interesting pockets." in: Experimental cell research, Vol. 264, Issue 1, pp. 135-47, (2001) (PubMed).
Synonyms and alternative names related to p130
retinoblastoma-like 2 (p130) (RBL2), RB transcriptional corepressor like 2 (RBL2), related to retinoblastoma 2 (LOC541652), RB transcriptional corepressor like 2 (Rbl2), p130, P130, PRB2, Rb2, RBL2, RBR-2, RBR2, RRB2aProtein level used designations for p130
- retinoblastoma-like 2 (p130)
- retinoblastoma-like protein 2
- retinoblastoma-like protein 2-like
- CL1187_-3
- CL1187_-3(342)
- CL1187_-3_ov
- PZA00193
- RB
- RRB2b
- Retinoblastoma-related protein 2
- nPZA00193.2
- retinoblastoma-related protein 2a
- 130 kDa retinoblastoma-associated protein
- retinoblastoma-related protein 2
- P130
- PPAR-alpha-interacting complex protein 128
- PRB2
- PRIC128
- RBR-2
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