p107 Products
(Retinoblastoma-Like 1 (p107) (RBL1))
Categories
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured p107 Categories
p107 Antibodies
High quality antibodies with extensive validation data.
p107 ELISA Kits
Reliable ELISA kits for a wide range of species.
p107 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended p107 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN389640
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, PLA
Validations
- (3)
Cat. No.
ABIN562602
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (2)
Cat. No.
ABIN6263929
Quantity
100 μL
Datasheet
Datasheet
Recommended p107 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969920
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1155324
Quantity
96 tests
Datasheet
Datasheet
Recommended p107 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317569
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094884
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3135610
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our p107 products
: "XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies." in: Oncotarget, Vol. 9, Issue 77, pp. 34567-34581, (2018) (PubMed).: "p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation." in: Bone, Vol. 69, pp. 47-54, (2014) (PubMed).
: "The 140-kD isoform of CD56 (NCAM1) directs the molecular pathogenesis of ischemic cardiomyopathy." in: The American journal of pathology, Vol. 182, Issue 4, pp. 1205-18, (2013) (PubMed).
: "B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29863-73, (2010) (PubMed).
: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).
: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." in: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, (2009) (PubMed).
: "p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2." in: The Journal of cell biology, Vol. 168, Issue 1, pp. 55-66, (2005) (PubMed).
: "The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain." in: The Journal of biological chemistry, Vol. 278, Issue 45, pp. 44255-64, (2003) (PubMed).
: "Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 15601-6, (2003) (PubMed).
: "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300." in: Genes & development, Vol. 9, Issue 10, pp. 1188-98, (1995) (PubMed).
Synonyms and alternative names related to p107
retinoblastoma-like 1 L homeolog (rbl1.L), RB transcriptional corepressor like 1 (RBL1), retinoblastoma-like 1 (p107) (rbl1), retinoblastoma-like 1 (rbl1), retinoblastoma-like 1 (p107) (RBL1), RB transcriptional corepressor like 1 (rbl1), retinoblastoma-like 1 (p107) (Rbl1), RB transcriptional corepressor like 1 (Rbl1), AW547426, CP107, fj58e06, p107, prb1, PRB1, wu:fj58e06Protein level used designations for p107
- retinoblastoma-like 1 (p107)
- retinoblastoma-like protein 1
- retinoblastoma-like protein 1-like
- 107 kDa retinoblastoma-associated protein
- cellular protein 107
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