Patched 1 Products
(Patched 1 (PTCH1))
Categories
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008].
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Featured Patched 1 Categories
Patched 1 Antibodies
High quality antibodies with extensive validation data.
Patched 1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Patched 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Patched 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC, IF
Validations
- (2)
- (7)
Cat. No.
ABIN185521
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (6)
Cat. No.
ABIN7255007
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (8)
Cat. No.
ABIN3015343
Quantity
100 μL
Datasheet
Datasheet
Recommended Patched 1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958422
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381402
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1152106
Quantity
96 tests
Datasheet
Datasheet
Recommended Patched 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316702
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316700
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505336
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Patched 1 products
: "Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo." in: International journal of cancer, Vol. 143, Issue 1, pp. 199-211, (2019) (PubMed).: "Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling." in: Experimental cell research, Vol. 371, Issue 2, pp. 417-425, (2018) (PubMed).
: "Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment." in: Biology of reproduction, Vol. 96, Issue 2, pp. 313-326, (2017) (PubMed).
: "Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway." in: Life sciences, Vol. 191, pp. 82-89, (2017) (PubMed).
: "Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate." in: PLoS genetics, Vol. 12, Issue 10, pp. e1006352, (2016) (PubMed).
: "Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma." in: Molecular cancer therapeutics, Vol. 15, Issue 5, pp. 1095-105, (2016) (PubMed).
: "Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen." in: Experimental neurology, Vol. 271, pp. 493-505, (2015) (PubMed).
: "Developmental Status: Impact of Short-Term Ischemia on Follicular Survival of Whole Ovarian Transplantation in a Rabbit Model." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135049, (2015) (PubMed).
: "Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling." in: Journal of neuro-oncology, Vol. 119, Issue 2, pp. 243-51, (2014) (PubMed).
: "High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma." in: OncoTargets and therapy, Vol. 7, pp. 79-86, (2014) (PubMed).
Synonyms and alternative names related to Patched 1
patched 1 (PTCH1), patched 1 (ptch1), patched 1 (Ptch1), patched 1 L homeolog (ptch1.L), Protein patched homolog 1 (ptc-1), A230106A15Rik, BCNS, HPE7, lep, mes, NBCCS, patched, patched1, PTC, Ptc, Ptc-1, PTC1, ptc1, Ptc1, ptc2, PTCH, Ptch, Ptch2, PTCH11, XPtc1Protein level used designations for Patched 1
- PTCH protein +12b
- PTCH protein +4'
- PTCH protein -10
- PTCH protein -3,4,5
- protein patched homolog 1
- leprechaun
- patched 2
- patched homolog 2
- patched homolog 1
- patched-1
- patched 1
- patched-like
- protein patched homolog 1-like
- Patched 1
- Ptch1 protein +12b
- mesenchymal dysplasia
- PTC1
- patched protein
- patched-like protein
- LOW QUALITY PROTEIN: protein patched homolog 1
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