PARL Products
(Presenilin Associated, Rhomboid-Like (PARL))
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This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured PARL Categories
PARL Antibodies
High quality antibodies with extensive validation data.
PARL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PARL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC
Validations
- (1)
- (5)
Cat. No.
ABIN2782038
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN634971
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7164273
Quantity
100 μL
Datasheet
Datasheet
Recommended PARL Proteins
Latest Publications for our PARL products
: "The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 11, pp. 1658-65, (2013) (PubMed).: "Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons." in: Nature, Vol. 452, Issue 7183, pp. 98-102, (2008) (PubMed).
: "Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling." in: Cell, Vol. 126, Issue 1, pp. 163-75, (2006) (PubMed).
: "Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18562-7, (2006) (PubMed).
: "Mitochondrial membrane remodelling regulated by a conserved rhomboid protease." in: Nature, Vol. 423, Issue 6939, pp. 537-41, (2003) (PubMed).
: "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2." in: Journal of Alzheimer's disease : JAD, Vol. 3, Issue 2, pp. 181-190, (2002) (PubMed).
Synonyms and alternative names related to PARL
presenilin associated rhomboid like (PARL), presenilin associated, rhomboid-like (Parl), presenilin associated rhomboid like (Parl), presenilin associated, rhomboid-like a (parla), D16Ertd607e, parl, PRO2207, PSARL, Psarl, PSARL1, PSENIP2, RHBDS1, zgc:112986Protein level used designations for PARL
- mitochondrial intramembrane cleaving protease PARL
- mitochondrial intramembrane-cleaving protease PARL
- presenilins-associated rhomboid-like protein, mitochondrial
- rhomboid 7 homolog 1
- presenilin associated, rhomboid-like isoform 1 preproprotein
- presenilin associated, rhomboid-like preproprotein
- parlb
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