Parkin Products
(Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
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The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008].
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Featured Parkin Categories
Parkin Antibodies
High quality antibodies with extensive validation data.
Parkin ELISA Kits
Reliable ELISA kits for a wide range of species.
Parkin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Parkin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, FACS, IHC (p)
Validations
- (6)
Cat. No.
ABIN390366
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (5)
Cat. No.
ABIN562106
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (10)
Cat. No.
ABIN3021179
Quantity
100 μL
Datasheet
Datasheet
Recommended Parkin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969157
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6958411
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381401
Quantity
96 tests
Datasheet
Datasheet
Recommended Parkin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124320
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314008
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314010
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Parkin products
: "PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation." in: Redox biology, Vol. 26, pp. 101254, (2019) (PubMed).: "Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases." in: Frontiers in pharmacology, Vol. 7, pp. 100, (2016) (PubMed).
: "Restoring Pharmacologic Preconditioning in the Aging Heart: Role of Mitophagy/Autophagy." in: The journals of gerontology. Series A, Biological sciences and medical sciences, (2016) (PubMed).
: "Ethanol-induced mitophagy in liver is associated with activation of the PINK1-Parkin pathway triggered by oxidative DNA damage." in: Histology and histopathology, Vol. 31, Issue 10, pp. 1143-59, (2016) (PubMed).
: "In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146083, (2016) (PubMed).
: "Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro." in: Cell and tissue research, Vol. 364, Issue 3, pp. 465-74, (2016) (PubMed).
: "ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts." in: Scientific reports, Vol. 6, pp. 24700, (2016) (PubMed).
: "Expression pattern of parkin isoforms in lung adenocarcinomas." in: Tumour biology, (2015) (PubMed).
: "Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance." in: Molecular neurobiology, Vol. 53, Issue 9, pp. 6270-6287, (2015) (PubMed).
: "Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant ?-synuclein." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 21, Issue 5, pp. 704-11, (2014) (PubMed).
Synonyms and alternative names related to Parkin
parkin (park), parkin RBR E3 ubiquitin protein ligase (PRKN), parkin RBR E3 ubiquitin protein ligase (Prkn), parkin RBR E3 ubiquitin protein ligase (prkn), parkin (CpipJ_CPIJ014867), Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2), AR-JP, CG10523, Dmel\\CG10523, Dpark, dpk, LPRS2, Park, PARK2, PDJ, pdr-1, PRKN, Prkn, SD01679, si:ch211-123f21.1, zgc:112390Protein level used designations for Parkin
- CG10523-PB
- CG10523-PC
- D-parkin
- dparkin
- park-PB
- park-PC
- E3 ubiquitin-protein ligase parkin
- Parkinson disease (autosomal recessive, juvenile) 2, parkin
- parkinson juvenile disease protein 2
- parkin variant SV5DEL
- parkin
- parkin protein
- parkinson protein 2, E3 ubiquitin protein ligase (parkin)
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