PAK6 Products
(P21-Activated Kinase 6 (PAK6))
Categories
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
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Featured PAK6 Categories
PAK6 Antibodies
High quality antibodies with extensive validation data.
PAK6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PAK6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF
Validations
- (4)
Cat. No.
ABIN656098
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
Cat. No.
ABIN3032120
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN528014
Quantity
100 μg
Datasheet
Datasheet
Recommended PAK6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6218404
Quantity
96 tests
Datasheet
Datasheet
Recommended PAK6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313930
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505270
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509060
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PAK6 products
: "Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein." in: Oncogene, Vol. 37, Issue 13, pp. 1730-1742, (2019) (PubMed).: "Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells." in: Oncotarget, Vol. 7, Issue 38, pp. 61229-61245, (2016) (PubMed).
: "P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion." in: The Journal of biological chemistry, Vol. 288, Issue 5, pp. 3025-35, (2013) (PubMed).
: "Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 7, pp. 3759-66, (2012) (PubMed).
: "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase." in: The Journal of biological chemistry, Vol. 280, Issue 5, pp. 3323-30, (2005) (PubMed).
: "Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1922-31, (2004) (PubMed).
: "Identification of an autoinhibitory domain of p21-activated protein kinase 5." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 33621-4, (2003) (PubMed).
: "p21-activated kinases: three more join the Pak." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 7, pp. 713-7, (2002) (PubMed).
: "AR and ER interaction with a p21-activated kinase (PAK6)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 1, pp. 85-99, (2002) (PubMed).
: "Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain." in: Oncogene, Vol. 21, Issue 24, pp. 3939-48, (2002) (PubMed).
Synonyms and alternative names related to PAK6
p21 (RAC1) activated kinase 6 (PAK6), p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6), p21 (RAC1) activated kinase 6 (Pak6), p21 protein (Cdc42/Rac)-activated kinase 6b (pak6b), p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), 4732456M09, PAK5, pak6, si:ch211-158b22.3Protein level used designations for PAK6
- p21(CDKN1A)-activated kinase 6
- serine/threonine-protein kinase PAK 6
- PAK-6
- p21-activated kinase 6
- p21 (CDKN1A)-activated kinase 6
- p21 protein (Cdc42/Rac)-activated kinase 6
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