PABPC4 Products
(Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))
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Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
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Featured PABPC4 Categories
PABPC4 Antibodies
High quality antibodies with extensive validation data.
Recommended PABPC4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6145149
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IP
Validations
- (2)
Cat. No.
ABIN6264006
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Dog, Horse, Human, Monkey, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN202848
Quantity
100 μL
Datasheet
Datasheet
Recommended PABPC4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229821
Quantity
96 tests
Datasheet
Datasheet
Recommended PABPC4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
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Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3085250
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PABPC4 products
: "N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis." in: Nature communications, Vol. 10, Issue 1, pp. 4596, (2019) (PubMed).: "Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma." in: Molecular & cellular proteomics : MCP, Vol. 15, Issue 7, pp. 2396-410, (2016) (PubMed).
: "Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation." in: Molecular and cellular biology, Vol. 34, Issue 7, pp. 1300-9, (2014) (PubMed).
: "Enhanced translation of mRNAs encoding proteins involved in mRNA translation during recovery from heat shock." in: PLoS ONE, Vol. 8, Issue 5, pp. e64171, (2013) (PubMed).
: "Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells." in: PLoS ONE, Vol. 7, Issue 12, pp. e53036, (2013) (PubMed).
: "Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis." in: Journal of genetics and genomics = Yi chuan xue bao, Vol. 39, Issue 8, pp. 369-74, (2012) (PubMed).
: "N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD." in: Nucleic acids research, Vol. 40, Issue 3, pp. 1251-66, (2012) (PubMed).
: "Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes." in: Journal of virology, Vol. 84, Issue 24, pp. 12934-44, (2010) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
Synonyms and alternative names related to PABPC4
polyadenylate-binding protein 4 (Bm1_06880), poly(A) binding protein, cytoplasmic 4 (Pabpc4), poly(A) binding protein, cytoplasmic 4 (inducible form) (pabpc4), poly(A) binding protein cytoplasmic 4 L homeolog (pabpc4.L), poly(A) binding protein cytoplasmic 4 (PABPC4), APP-1, APP1, cb12, ePAB, ePABP, iPABP, PABP, PABP4, sb:cb12Protein level used designations for PABPC4
- polyadenylate-binding protein 4
- poly(A) binding protein, cytoplasmic 4 (inducible form)
- PABP-4
- activated-platelet protein 1
- inducible poly(A)-binding protein
- poly(A)-binding protein 4
- poly A binding protein, cytoplasmic 4
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