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OS9 Products

(Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9))

Categories

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Featured OS9 Categories

OS9 Antibodies

High quality antibodies with extensive validation data.

OS9 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended OS9 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7165899
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (4)
Cat. No. ABIN5014064
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, ICC, IF
Validations
  • (2)
Cat. No. ABIN6263908
Quantity 100 μL
Datasheet Datasheet

Recommended OS9 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6227499
Quantity 96 tests
Datasheet Datasheet

Recommended OS9 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313668
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419172
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419175
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our OS9 products

Sun, Xu, Chen, Yu, Yang, Qiu, Peng, Wang, Xiao, Yang: "A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway." in: International journal of biological sciences, Vol. 11, Issue 6, pp. 664-71, (2015) (PubMed).

Chen, Yin, Lao, Liang, He, Wang, Sang: "AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol." in: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 15, pp. 2520-36, (2015) (PubMed).

Tang, Huang, Zhuang, Christianson, Chen: "EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog." in: PLoS ONE, Vol. 9, Issue 6, pp. e92164, (2014) (PubMed).

Sun, Chen, Li, Huo, Liu, Hua, Zhang, Liu, Yang, Fu, Yan, Hong, Cao: "A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma." in: British journal of cancer, Vol. 111, Issue 11, pp. 2131-41, (2014) (PubMed).

Koenig, Nicholls, Schmidt, Hagiwara, Maruyama, Frydman, Watson, Page, Ploegh: "The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice." in: The Journal of biological chemistry, Vol. 289, Issue 50, pp. 34490-502, (2014) (PubMed).

Hofmann, Fischer, Nothnagel, Jacobs, Schmid, Wittig, Franke, Gaede, Schürmann, Petrek, Mrazek, Pabst, Grohé, Grunewald, Ronninger, Eklund, Rosenstiel, Höhne, Zissel, Müller-Quernheim, Schreiber: "Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis." in: The European respiratory journal, Vol. 41, Issue 4, pp. 888-900, (2013) (PubMed).

Huang, Hsiao, Chu, Ye, Chen: "Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 288, Issue 35, pp. 25330-9, (2013) (PubMed).

Bernasconi, Galli, Noack, Bianchi, de Haan, Reggiori, Molinari: "Role of the SEL1L:LC3-I complex as an ERAD tuning receptor in the mammalian ER." in: Molecular cell, Vol. 46, Issue 6, pp. 809-19, (2012) (PubMed).

Dougan, Hu, Paquet, Greenblatt, Kim, Lilley, Watson, Ploegh: "Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes." in: Molecular and cellular biology, Vol. 31, Issue 6, pp. 1145-59, (2011) (PubMed).

Brockmeier, Platzek, Schneider, Patak, Bernardini, Fandrey, Metzen: "The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9." in: PLoS ONE, Vol. 6, Issue 4, pp. e19151, (2011) (PubMed).

Synonyms and alternative names related to OS9

OS9, endoplasmic reticulum lectin (OS9), osteosarcoma amplified 9, endoplasmic reticulum lectin (os9), amplified in osteosarcoma (Os9), OS9, endoplasmic reticulum lectin (Os9), 4632413K17Rik, AU022351, ERLEC2, OS-9, Os-9, zgc:153838

Protein level used designations for OS9

  • amplified in osteosarcoma
  • osteosarcoma amplified 9, endoplasmic reticulum associated protein
  • protein OS-9
  • osteosarcoma amplified 9
  • amplified in osteosarcoma 9
  • endoplasmic reticulum lectin 2
  • erlectin 2
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