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ORC2 Products

(Origin Recognition Complex Subunit 2 (ORC2))
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010].

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Featured ORC2 Categories

ORC2 Antibodies

High quality antibodies with extensive validation data.

ORC2 ELISA Kits

Reliable ELISA kits for a wide range of species.

ORC2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ORC2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (1)
  • (5)
Cat. No. ABIN562076
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN2855601
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (1)
  • (1)
Cat. No. ABIN108579
Quantity 50 μL
Datasheet Datasheet

Recommended ORC2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1146513
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1146514
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1146515
Quantity 96 tests
Datasheet Datasheet

Recommended ORC2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313650
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094298
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3122769
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ORC2 products

Murai, Tang, Leo, Baechler, Redon, Zhang, Al Abo, Rajapakse, Nakamura, Jenkins, Aladjem, Pommier: "SLFN11 Blocks Stressed Replication Forks Independently of ATR." in: Molecular cell, Vol. 69, Issue 3, pp. 371-384.e6, (2019) (PubMed).

Ehlén, Nodin, Rexhepaj, Brändstedt, Uhlén, Alvarado-Kristensson, Pontén, Brennan, Jirström: "RBM3-regulated genes promote DNA integrity and affect clinical outcome in epithelial ovarian cancer." in: Translational oncology, Vol. 4, Issue 4, pp. 212-21, (2011) (PubMed).

Song, Levin, Varkey, Post, Bermudez, Hurwitz, Tomkinson: "A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes." in: The Journal of biological chemistry, Vol. 282, Issue 31, pp. 22721-30, (2007) (PubMed).

Quintana, Hou, Thome, Hendricks, Saha, Dutta: "Identification of HsORC4, a member of the human origin of replication recognition complex." in: The Journal of biological chemistry, Vol. 272, Issue 45, pp. 28247-51, (1997) (PubMed).

Takahara, Bong, Brevard, Eddy, Haley, Sait, Shows, Hoffman, Greenspan: "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L." in: Genomics, Vol. 31, Issue 1, pp. 119-22, (1996) (PubMed).

Synonyms and alternative names related to ORC2

Origin recognition complex subunit 2 (Orc2), origin recognition complex second largest subunit 2 (ORC2), origin recognition complex subunit 2 (ORC2), origin recognition complex, subunit 2 (Orc2), origin recognition complex subunit 2 S homeolog (orc2.S), Origin recognition complex subunit 2 (orc-2), ATORC2, AU041563, CG3041, Dmel\\CG3041, DmORC 2, DmORC2, DmOrc2, DmOrc2p, F13M22.6, F13M22_6, fs(3)293, fs(3)293-19, k43, l(3)88Ab, l(3)A5, l(3)dsl5, l(3)K43, l(3)k43, l(3)SG44, ORC, Orc-2, ORC2, orc2, orc2-a, ORC2L, Orc2l, orc2l, Orc2p, ORIGIN RECOGNITION COMPLEX SECOND LARGEST SUBUNIT 2, origin recognition complex second largest subunit 2, rDmORC, xorc2

Protein level used designations for ORC2

  • CG3041-PA
  • Orc2-PA
  • lethal(3)88Ab
  • origin recognition complex
  • origin recognition complex subunit 2
  • origin recognition complex protein 2 homolog
  • origin recognition complex, subunit 2 homolog
  • origin recognition complex, subunit 2-like
  • origin recognition complex subunit 2 homolog
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