ORAI1 Products
(ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))
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The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011].
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Featured ORAI1 Categories
ORAI1 Antibodies
High quality antibodies with extensive validation data.
ORAI1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended ORAI1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC, FACS, IF, LCI, ICC
Validations
- (6)
Cat. No.
ABIN7043408
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7146306
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN6263901
Quantity
100 μL
Datasheet
Datasheet
Recommended ORAI1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1124739
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1124740
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1124741
Quantity
96 tests
Datasheet
Datasheet
Recommended ORAI1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3117264
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3125369
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ORAI1 products
: "Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion." in: Frontiers in physiology, Vol. 9, pp. 813, (2018) (PubMed).: "Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells." in: The Journal of biological chemistry, Vol. 291, Issue 40, pp. 21148-21159, (2016) (PubMed).
: "Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression." in: Cell reports, Vol. 12, Issue 2, pp. 203-16, (2015) (PubMed).
: "Molecular mechanisms of spontaneous and directed mast cell motility." in: Journal of leukocyte biology, Vol. 92, Issue 5, pp. 1029-41, (2012) (PubMed).
: "Selective activation of the transcription factor NFAT1 by calcium microdomains near Ca2+ release-activated Ca2+ (CRAC) channels." in: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 14795-803, (2011) (PubMed).
: "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 48, pp. 19234-9, (2011) (PubMed).
: "Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome." in: Human molecular genetics, Vol. 19, Issue 20, pp. 4026-42, (2010) (PubMed).
: "Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8." in: Molecular pharmacology, Vol. 75, Issue 4, pp. 830-42, (2009) (PubMed).
: "Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis." in: Nature cell biology, Vol. 11, Issue 12, pp. 1465-72, (2009) (PubMed).
: "Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 8, pp. 2425-37, (2009) (PubMed).
Synonyms and alternative names related to ORAI1
ORAI calcium release-activated calcium modulator 1 (ORAI1), ORAI calcium release-activated calcium modulator 1 (Orai1), ORAI calcium release-activated calcium modulator 1b (orai1b), ORAI calcium release-activated calcium modulator 1 S homeolog (orai1.S), ORAI calcium release-activated calcium modulator 1 (orai1), CRACM1, D730049H07Rik, im:7146264, LOC100218031, orai-1, orai1, ORAI1, orai2, ORAT1, RGD1311873, TMEM142A, Tmem142a, tmem142a, zgc:109721Protein level used designations for ORAI1
- calcium release-activated calcium channel protein 1
- calcium release-activated calcium modulator 1
- protein orai-1
- transmembrane protein 142A
- calcium release-activated calcium channel 1
- ORAI calcium release-activated calcium modulator 1
- protein orai-2
- transmembrane protein 142B
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