OPTN Products
(Optineurin (OPTN))
Categories
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Featured OPTN Categories
OPTN Antibodies
High quality antibodies with extensive validation data.
OPTN ELISA Kits
Reliable ELISA kits for a wide range of species.
OPTN Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended OPTN Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7435085
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (4)
Cat. No.
ABIN2178063
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, IHC (p), IF, ICC
Validations
- (4)
Cat. No.
ABIN2856108
Quantity
100 μL
Datasheet
Datasheet
Recommended OPTN ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958311
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958312
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951202
Quantity
96 tests
Datasheet
Datasheet
Recommended OPTN Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124266
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313422
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313421
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our OPTN products
: "Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients." in: Immunology, Vol. 144, Issue 1, pp. 45-55, (2014) (PubMed).: "Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro." in: International immunology, Vol. 9, Issue 7, pp. 935-44, (1997) (PubMed).
: "Identification of a monoclonal antibody specific for a murine T3 polypeptide." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 5, pp. 1374-8, (1987) (PubMed).
Synonyms and alternative names related to OPTN
optineurin (OPTN), optineurin (optn), optineurin (Optn), optineurin L homeolog (optn.L), 4930441O07Rik, ALS12, fip2, FIP2, Fip2, fj52f04, glc1e, GLC1E, hip7, HIP7, hypl, HYPL, nrp, NRP, si:ch211-240l19.3, tfiiia-intp, TFIIIA-INTP, wu:fj52f04, zgc:66386, zgc:77868Protein level used designations for OPTN
- optineurin
- optineurin-like
- E3-14.7K-interacting protein
- FIP-2
- HIP-7
- Huntingtin interacting protein L
- huntingtin yeast partner L
- huntingtin-interacting protein 7
- huntingtin-interacting protein L
- nemo-related protein
- optic neuropathy-inducing protein
- transcription factor IIIA-interacting protein
- transcrption factor IIIA-interacting protein
- tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
- 14.7K-interacting protein 2
- FIP-2-like protein
- TFIIIA-INTP
- ag9-C5
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