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OGT Products

(O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:polypeptide-N-Acetylglucosaminyl Transferase) (OGT))
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

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Featured OGT Categories

OGT Antibodies

High quality antibodies with extensive validation data.

OGT ELISA Kits

Reliable ELISA kits for a wide range of species.

OGT Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended OGT Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC, IF, FACS
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  • (6)
Cat. No. ABIN190863
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), IP, ICC, FACS
Validations
  • (8)
Cat. No. ABIN2856718
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
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Cat. No. ABIN3022708
Quantity 100 μL
Datasheet Datasheet

Recommended OGT ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958285
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5657483
Quantity 96 tests
Datasheet Datasheet

Recommended OGT Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
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Cat. No. ABIN1313359
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710043
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727888
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our OGT products

Lucena, Carvalho-Cruz, Donadio, Oliveira, de Queiroz, Marinho-Carvalho, Sola-Penna, de Paula, Gondim, McComb, Costello, Whelan, Todeschini, Dias: "Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation." in: The Journal of biological chemistry, Vol. 291, Issue 25, pp. 12917-29, (2016) (PubMed).

Banerjee, Sangwan, McGinn, Chugh, Dudeja, Vickers, Saluja: "Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1." in: The Journal of biological chemistry, Vol. 288, Issue 47, pp. 33927-38, (2013) (PubMed).

Ise, Goto, Komura, Akaike: "Engulfment and clearance of apoptotic cells based on a GlcNAc-binding lectin-like property of surface vimentin." in: Glycobiology, Vol. 22, Issue 6, pp. 788-805, (2012) (PubMed).

Allison, Wamsley, Kumar, Li, Gray, Hart, Jones, Mayo: "Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-?B acetylation and transcription." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 42, pp. 16888-93, (2012) (PubMed).

Taylor, Parker, Hazel, Soesanto, Fuller, Yazzie, McClain: "Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase." in: The Journal of biological chemistry, Vol. 283, Issue 10, pp. 6050-7, (2008) (PubMed).

Majumdar, Wright, Markowitz, Martinez-Hernandez, Raghow, Solomon: "Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1." in: Diabetes, Vol. 53, Issue 12, pp. 3184-92, (2004) (PubMed).

Synonyms and alternative names related to OGT

O-linked N-acetylglucosamine (GlcNAc) transferase L homeolog (ogt.L), super sex combs (sxc), O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 (ogt.1), O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), O-linked N-acetylglucosamine (GlcNAc) transferase (ogt), O-linked GlcNAc transferase (GL50803_12081), O-linked GlcNAc transferase (GL50803_41701), o-linked GlcNAc transferase (THAPSDRAFT_264441), O-linked GlcNAc transferase (spyA), O-linked N-acetylglucosamine (GlcNAc) transferase (Ogt), O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (Ogt), 1110038P24Rik, 4831420N21Rik, AI115525, BcDNA:GH04245, CG10392, Dmel\\CG10392, fm81g08, HRNT1, l(2)02637, l(2)NC130, O-GLCNAC, OGT, Ogt, ogt, Ogtl, P1201, SXC, Sxc, sxc/Ogt, wu:fc12b01, wu:fm81g08

Protein level used designations for OGT

  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
  • O-linked GlcNAc transferase
  • UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
  • CG10392-PA
  • CG10392-PB
  • CG10392-PC
  • O-glycosyltransferase
  • O-linked N-acetylglucosamine transferase
  • lethal (2) NC130
  • sxc-PA
  • sxc-PB
  • sxc-PC
  • O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1
  • copy I
  • ogta
  • UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
  • o-linked GlcNAc transferase
  • TPR repeat-containing protein
  • UDP-N-acetylglucosamine:peptide N-acetylglucosaminyltransferase
  • O linked N-acetylglucosamine transferase
  • O-GlcNAc transferase subunit p110
  • O-linked N-acetylglucosamine transferase 110 kDa subunit
  • UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
  • O-GlcNAc transferase p110 subunit
  • uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
  • O linked N-acetylglucosamine transferase like
  • UDP-N-acetylglucosaminyltransferase
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