OAS1B Products
(2'-5' Oligoadenylate Synthetase 1B (OAS1B))
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This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008].
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Featured OAS1B Categories
OAS1B Antibodies
High quality antibodies with extensive validation data.
Recommended OAS1B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
West Nile Virus (WNV)
Application
IF, ELISA, WB
Validations
- (3)
- (1)
Cat. No.
ABIN2477148
Quantity
0.1 mg
Datasheet
Datasheet
Recommended OAS1B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3122767
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our OAS1B products
: "Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein." in: The Journal of general virology, Vol. 86, Issue Pt 2, pp. 405-12, (2005) (PubMed).: "West Nile virus: a growing concern?" in: The Journal of clinical investigation, Vol. 113, Issue 8, pp. 1102-7, (2004) (PubMed).
: "Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells." in: The Journal of biological chemistry, Vol. 279, Issue 52, pp. 54533-41, (2004) (PubMed).
Synonyms and alternative names related to OAS1B
2'-5' oligoadenylate synthetase 1B (Oas1b), 2-5 oligoadenylate synthetase 1B (Oas1b), (2-5')oligo(A) synthase 1B, 2-5A synthase 1B, Flv, L1, Mmu-L1, Oas1, Oias-2, Oias2, WnvProtein level used designations for OAS1B
- (2-5')oligo(A) synthase 1B
- (2-5')oligo(A) synthetase 1b
- 2',5'-oligoadenylate synthetase-like 1
- 2'-5'-oligoadenylate synthase 1B
- 2'-5'-oligoadenylate synthase-like protein 1
- 2'-5'-oligoadenylate synthetase-like protein 1
- 2-5A synthase 1B
- 2-5A synthetase 1B
- Flavivirus resistance
- inactive 2'-5'-oligoadenylate synthase 1B
- 2'5' oligoadenylate synthetase-2
- 25 oligoadenylate synthetase-2
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