OAS1 Products
(2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
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This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured OAS1 Categories
OAS1 Antibodies
High quality antibodies with extensive validation data.
OAS1 ELISA Kits
Reliable ELISA kits for a wide range of species.
OAS1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended OAS1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7435079
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7435082
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (7)
- (3)
Cat. No.
ABIN390164
Quantity
400 μL
Datasheet
Datasheet
Recommended OAS1 ELISA Kits
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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5593383
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Validations
Cat. No.
ABIN1118759
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5651266
Quantity
96 tests
Datasheet
Datasheet
Recommended OAS1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1313295
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121603
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313297
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our OAS1 products
: "Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells." in: Immunology and cell biology, Vol. 92, Issue 2, pp. 105-15, (2014) (PubMed).: "RIG-I-like receptors mediate innate antiviral response in mouse testis." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 9, pp. 1455-67, (2013) (PubMed).
: "The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization." in: Lung cancer (Amsterdam, Netherlands), Vol. 78, Issue 1, pp. 30-8, (2012) (PubMed).
: "Higher miRNA tolerance in immortal Li-Fraumeni fibroblasts with abrogated interferon signaling pathway." in: Cancer research, Vol. 71, Issue 1, pp. 255-65, (2011) (PubMed).
: "Azithromycin induces anti-viral responses in bronchial epithelial cells." in: The European respiratory journal, Vol. 36, Issue 3, pp. 646-54, (2010) (PubMed).
: "The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 28343-51, (2009) (PubMed).
: "Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15845-52, (2008) (PubMed).
: "IFI16 in human prostate cancer." in: Molecular cancer research : MCR, Vol. 5, Issue 3, pp. 251-9, (2007) (PubMed).
: "A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L." in: Journal of virology, Vol. 81, Issue 11, pp. 5561-72, (2007) (PubMed).
: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).
Synonyms and alternative names related to OAS1
2',5'-oligoadenylate synthetase 1 (OAS1), 2'-5'-oligoadenylate synthetase 1 (OAS1), 2'-5' oligoadenylate synthetase 1A (Oas1a), protein phosphatase 2 catalytic subunit beta (Ppp2cb), 2'-5'-oligoadenylate synthetase 1 (Oas1), IFI-4, L3, OAS1, OIAS, OIASI, Pp2a2Protein level used designations for OAS1
- 2',5'-oligoadenylate synthetase 1
- 2',5'-oligoadenylate synthetase 1, 40/46kDa
- 2'-5'-oligoadenylate synthase 1
- (2-5')oligo(A) synthase 1
- (2-5')oligo(A) synthetase 1
- 2'-5' oligoadenylate synthetase
- 2-5A synthase 1
- 2-5A synthetase 1
- p42 OAS
- 2-5-oligoadenylate synthetase 1
- 2'-5' oligoadenylate synthetase 1
- 2',5'-oligo A synthetase 1
- 2'-5' oligoadenylate synthetase 1 p48 isoform
- 2'-5' oligoadenylate synthetase 1 p52 isoform
- 2'-5'-oligoisoadenylate synthetase 1
- E18/E16
- p46/p42 OAS
- 2'-5'-oligoadenylate synthetase 1-like
- 2'-5'-oligoadenylate synthetase 1, 40/46kDa
- (2-5')oligo(A) synthase 1A
- (2-5')oligo(A) synthetase 1A
- 2'-5'-oligoadenylate synthase 1A
- 2-5A synthase 1A
- 2-5A synthetase 1A
- PP2A-beta
- protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
- protein phosphatase 2, catalytic subunit, beta isoform
- protein phosphatase 2A catalytic alpha subunit
- protein phosphatase 2a, catalytic subunit, beta isoform
- protein phosphatase-2A-beta
- serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1
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