NUP98 Products
(Nucleoporin 98kDa (NUP98))
Categories
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described. [provided by RefSeq, May 2010].
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Featured NUP98 Categories
NUP98 Antibodies
High quality antibodies with extensive validation data.
NUP98 ELISA Kits
Reliable ELISA kits for a wide range of species.
NUP98 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NUP98 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Application
WB, ELISA, IF, ICC, DB
Validations
- (2)
- (14)
Cat. No.
ABIN2452066
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena
Application
WB, IF
Validations
- (2)
- (8)
Cat. No.
ABIN2452064
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Tetrahymena
Application
WB, IF
Validations
- (2)
- (8)
Cat. No.
ABIN2452065
Quantity
100 μg
Datasheet
Datasheet
Recommended NUP98 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1116273
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN511450
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN512355
Quantity
96 tests
Datasheet
Datasheet
Recommended NUP98 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313246
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313248
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7406317
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NUP98 products
: "NPHP proteins are binding partners of nucleoporins at the base of the primary cilium." in: PLoS ONE, Vol. 14, Issue 9, pp. e0222924, (2019) (PubMed).: "Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia." in: Nature, Vol. 561, Issue 7721, pp. 127-131, (2018) (PubMed).
: "Tpr regulates the total number of nuclear pore complexes per cell nucleus." in: Genes & development, Vol. 32, Issue 19-20, pp. 1321-1331, (2018) (PubMed).
: "Evolution of a transcriptional regulator from a transmembrane nucleoporin." in: Genes & development, Vol. 30, Issue 10, pp. 1155-71, (2016) (PubMed).
: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).
: "Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 661-9, (2010) (PubMed).
: "Specific monoclonal antibody against the nuclear pore complex protein, nup98." in: Hybridoma (2005), Vol. 24, Issue 5, pp. 244-7, (2005) (PubMed).
Synonyms and alternative names related to NUP98
Nucleoporin 98-96kD (Nup98-96), nuclear pore complex protein Nup98-Nup96 (LOC408335), nucleoporin 98 (NUP98), nuclear pore complex protein Nup98-Nup96 (LOC587580), nucleoporin 98kDa (NUP98), nucleoporin 98 (Nup98), nucleoporin 98 (nup98), nucleoporin 98 L homeolog (nup98.L), 4732457F17, ADIR2, AI849286, CG10198, CG10201, Dmel\\CG10198, GB12688, im:7151238, l(3)95BCd, Nup-98, Nup 96, Nup96, NUP96, Nup 98, Nup98, NUP98, nup98-96, Nup98-Nup96, Nup98/96, nup145, NUP196, zgc:63593, zgc:113968Protein level used designations for NUP98
- CG10198-PA
- CG10198-PC
- CG10198-PD
- Nup98
- Nup98-96-PA
- Nup98-96-PC
- Nup98-96-PD
- nucleoporin 98
- nucleoporin 98-96
- nucleoporin98-96
- nucleoporin 98kD
- nucleoporin 98kDa
- nuclear pore complex protein Nup98-Nup96-like
- nuclear pore complex protein Nup98-Nup96
- 98 kDa nucleoporin
- nuclear pore complex protein Nup98
- nucleoporin Nup98
- GLFG-repeat containing nucleoporin
- Nup98-Nup96
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