NUMBL Products
(Numb Homolog (Drosophila)-Like (NUMBL))
Categories
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
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Featured NUMBL Categories
NUMBL Antibodies
High quality antibodies with extensive validation data.
NUMBL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NUMBL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7162085
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN6263771
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN658002
Quantity
400 μL
Datasheet
Datasheet
Recommended NUMBL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231602
Quantity
96 tests
Datasheet
Datasheet
Recommended NUMBL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131350
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094283
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2727806
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our NUMBL products
: "Progenitor cell maintenance requires numb and numblike during mouse neurogenesis." in: Nature, Vol. 419, Issue 6910, pp. 929-34, (2002) (PubMed).Synonyms and alternative names related to NUMBL
NUMB like, endocytic adaptor protein (NUMBL), numb homolog-like L homeolog (numbl.L), NUMB-like, endocytic adaptor protein (Numbl), numb-like (Numbl), cag3a, CAG3A, ctg3a, CTG3a, nbl, NBL, numb, numb-r, NUMB-R, numblike, NUMBLIKE, numbr, NUMBR, tnrc23, TNRC23Protein level used designations for NUMBL
- numb homolog-like
- numb-like protein
- numb-related protein
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