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NUMB Products

(Numb Homolog (NUMB))

Categories

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured NUMB Categories

NUMB Antibodies

High quality antibodies with extensive validation data.

NUMB ELISA Kits

Reliable ELISA kits for a wide range of species.

NUMB Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NUMB Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, IF, FACS
Validations
  • (9)
Cat. No. ABIN184679
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN6144943
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN563731
Quantity 100 μg
Datasheet Datasheet

Recommended NUMB ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4884024
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6385253
Quantity 96 tests
Datasheet Datasheet

Recommended NUMB Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313212
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405789
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405792
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our NUMB products

Wang, Xiang, Liu, He, Randle, Zhang, Dongre, Sachs, Clark, Tao, Chen, Botchkarev, Xie, Dai, Clevers, Li, Livingston: "Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer." in: Cell, Vol. 178, Issue 1, pp. 135-151.e19, (2019) (PubMed).

Cesur, Eren, Eren, Ergin, Ek, Yıldız, Şirinyıldız, Gök Balcı, Ongel: "Effect of experimentally induced hypothyroidism during gestation period on activity dependent neurotrophic factor (ADNF) in newborn rat brain tissue." in: Hormone molecular biology and clinical investigation, Vol. 36, Issue 3, (2018) (PubMed).

Lenihan, Saha, Heimer-McGinn, Cryan, Feng, Young: "Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice." in: Molecular neurobiology, (2016) (PubMed).

Mah, Soloff, Hedrick, Mariani: "Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway." in: Stem cell reports, Vol. 5, Issue 5, pp. 866-80, (2015) (PubMed).

Wu, Zhang, Liu, Yan, Liu, Xie, Zhang, Sun, Ke, Zhou: "Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy." in: Journal of physiology and biochemistry, Vol. 71, Issue 2, pp. 217-26, (2015) (PubMed).

Li, Fu, Zhang, Zhang, Xu, Ma, Li, Song: "The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1." in: Nature medicine, Vol. 20, Issue 1, pp. 80-6, (2014) (PubMed).

Colaluca, Tosoni, Nuciforo, Senic-Matuglia, Galimberti, Viale, Pece, Di Fiore: "NUMB controls p53 tumour suppressor activity." in: Nature, Vol. 451, Issue 7174, pp. 76-80, (2008) (PubMed).

Maiorano, Favia, Pece, Resta, Maisonneuve, Di Fiore, Capodiferro, Urbani, Viale: "Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas." in: International journal of immunopathology and pharmacology, Vol. 20, Issue 4, pp. 779-89, (2008) (PubMed).

Nishimura, Kaibuchi: "Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3." in: Developmental cell, Vol. 13, Issue 1, pp. 15-28, (2007) (PubMed).

Holowacz, Zeng, Lassar: "Asymmetric localization of numb in the chick somite and the influence of myogenic signals." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 235, Issue 3, pp. 633-45, (2006) (PubMed).

Synonyms and alternative names related to NUMB

NUMB, endocytic adaptor protein (NUMB), numb homolog (Drosophila) (Numb), NUMB, endocytic adaptor protein (Numb), numb homolog (Drosophila) (numb), C14orf41, c14_5527, Nb, S171

Protein level used designations for NUMB

  • h-Numb
  • protein numb homolog
  • numb gene homolog
  • numb homolog
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