NUMB Products
(Numb Homolog (NUMB))
Categories
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured NUMB Categories
NUMB Antibodies
High quality antibodies with extensive validation data.
NUMB ELISA Kits
Reliable ELISA kits for a wide range of species.
NUMB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NUMB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC, IF, FACS
Validations
- (9)
Cat. No.
ABIN184679
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN6144943
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN563731
Quantity
100 μg
Datasheet
Datasheet
Recommended NUMB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884024
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385253
Quantity
96 tests
Datasheet
Datasheet
Recommended NUMB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1313212
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405789
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405792
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NUMB products
: "Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer." in: Cell, Vol. 178, Issue 1, pp. 135-151.e19, (2019) (PubMed).: "Effect of experimentally induced hypothyroidism during gestation period on activity dependent neurotrophic factor (ADNF) in newborn rat brain tissue." in: Hormone molecular biology and clinical investigation, Vol. 36, Issue 3, (2018) (PubMed).
: "Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice." in: Molecular neurobiology, (2016) (PubMed).
: "Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway." in: Stem cell reports, Vol. 5, Issue 5, pp. 866-80, (2015) (PubMed).
: "Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy." in: Journal of physiology and biochemistry, Vol. 71, Issue 2, pp. 217-26, (2015) (PubMed).
: "The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1." in: Nature medicine, Vol. 20, Issue 1, pp. 80-6, (2014) (PubMed).
: "NUMB controls p53 tumour suppressor activity." in: Nature, Vol. 451, Issue 7174, pp. 76-80, (2008) (PubMed).
: "Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas." in: International journal of immunopathology and pharmacology, Vol. 20, Issue 4, pp. 779-89, (2008) (PubMed).
: "Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3." in: Developmental cell, Vol. 13, Issue 1, pp. 15-28, (2007) (PubMed).
: "Asymmetric localization of numb in the chick somite and the influence of myogenic signals." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 235, Issue 3, pp. 633-45, (2006) (PubMed).
Synonyms and alternative names related to NUMB
NUMB, endocytic adaptor protein (NUMB), numb homolog (Drosophila) (Numb), NUMB, endocytic adaptor protein (Numb), numb homolog (Drosophila) (numb), C14orf41, c14_5527, Nb, S171Protein level used designations for NUMB
- h-Numb
- protein numb homolog
- numb gene homolog
- numb homolog
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