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NUAK1 Products

(NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Categories

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.

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Featured NUAK1 Categories

NUAK1 Antibodies

High quality antibodies with extensive validation data.

NUAK1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NUAK1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Hamster, Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN392639
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN392640
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN716396
Quantity 100 μL
Datasheet Datasheet

Recommended NUAK1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6227500
Quantity 96 tests
Datasheet Datasheet

Recommended NUAK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313130
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1313129
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509049
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our NUAK1 products

Humbert, Navaratnam, Augert, Da Costa, Martien, Wang, Martinez, Abbadie, Carling, de Launoit, Gil, Bernard: "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." in: The EMBO journal, Vol. 29, Issue 2, pp. 376-86, (2010) (PubMed).

Niesler, Myburgh, Moore: "The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis." in: Experimental physiology, Vol. 92, Issue 1, pp. 207-17, (2007) (PubMed).

Suzuki, Lu, Kusakai, Kishimoto, Ogura, Esumi: "ARK5 is a tumor invasion-associated factor downstream of Akt signaling." in: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3526-35, (2004) (PubMed).

Kusakai, Suzuki, Ogura, Kaminishi, Esumi: "Strong association of ARK5 with tumor invasion and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 2, pp. 263-8, (2004) (PubMed).

Suzuki, Kusakai, Kishimoto, Lu, Ogura, Esumi: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation." in: Oncogene, Vol. 22, Issue 40, pp. 6177-82, (2003) (PubMed).

Suzuki, Kusakai, Kishimoto, Lu, Ogura, Lavin, Esumi: "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 48-53, (2002) (PubMed).

Synonyms and alternative names related to NUAK1

NUAK family kinase 1 (NUAK1), NUAK family, SNF1-like kinase, 1 (Nuak1), ARK5, AU014801, AW494241, B230104P22Rik, Omphk1

Protein level used designations for NUAK1

  • AMP-activated protein kinase family member 5
  • AMPK-related protein kinase 5
  • NUAK family SNF1-like kinase 1
  • omphalocele kinase 1
  • ZNUAK family, SNF1-like kinase, 1
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