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NSUN2 Products

(NOP2/Sun Domain Family, Member 2 (NSUN2))

Categories

This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011].

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Featured NSUN2 Categories

NSUN2 Antibodies

High quality antibodies with extensive validation data.

NSUN2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NSUN2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN1681117
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7173496
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6263746
Quantity 100 μL
Datasheet Datasheet

Recommended NSUN2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6231553
Quantity 96 tests
Datasheet Datasheet

Recommended NSUN2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094279
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3134928
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727652
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our NSUN2 products

Blanco, Bandiera, Popis, Hussain, Lombard, Aleksic, Sajini, Tanna, Cortés-Garrido, Gkatza, Dietmann, Frye: "Stem cell function and stress response are controlled by protein synthesis." in: Nature, Vol. 534, Issue 7607, pp. 335-40, (2016) (PubMed).

Chaumet, Wright, Seet, Tham, Gounko, Bard: "Nuclear envelope-associated endosomes deliver surface proteins to the nucleus." in: Nature communications, Vol. 6, pp. 8218, (2015) (PubMed).

Lv, Liu, Cheng, Yu, Xiong, Hu, Tang, Zeng, Sang: "SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer." in: Scientific reports, Vol. 5, pp. 17940, (2015) (PubMed).

Hussain, Tuorto, Menon, Blanco, Cox, Flores, Watt, Kudo, Lyko, Frye: "The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation." in: Molecular and cellular biology, Vol. 33, Issue 8, pp. 1561-70, (2013) (PubMed).

Horn, Kim, Wright, Wong, Stewart, Burke, Roux: "A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton." in: The Journal of cell biology, Vol. 202, Issue 7, pp. 1023-39, (2013) (PubMed).

Alsarraj, Faraji, Geiger, Mattaini, Williams, Wu, Ha, Merlino, Walker, Bosley, Xiao, Andresson, Esposito, Smithers, Lugo, Prinjha, Day, Crawford, Ozato, Gardner, Hunter: "BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane." in: PLoS ONE, Vol. 8, Issue 11, pp. e80746, (2013) (PubMed).

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Khan, Rafiq, Noor, Hussain, Flores, Rupp, Vincent, Malli, Ali, Khan, Ishak, Doherty, Weksberg, Ayub, Windpassinger, Ibrahim, Frye, Ansar, Vincent: "Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability." in: American journal of human genetics, Vol. 90, Issue 5, pp. 856-63, (2012) (PubMed).

Blanco, Kurowski, Nichols, Watt, Benitah, Frye: "The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate." in: PLoS genetics, Vol. 7, Issue 12, pp. e1002403, (2011) (PubMed).

Gudise, Figueroa, Lindberg, Larsson, Hallberg: "Samp1 is functionally associated with the LINC complex and A-type lamina networks." in: Journal of cell science, Vol. 124, Issue Pt 12, pp. 2077-85, (2011) (PubMed).

Synonyms and alternative names related to NSUN2

NOL1/NOP2/Sun domain family member 2 (Nsun2), NOP2/Sun RNA methyltransferase family member 2 (NSUN2), NOP2/Sun RNA methyltransferase family, member 2 (Nsun2), NOP2/Sun RNA methyltransferase family member 2 S homeolog (nsun2.S), D13Wsu123e, Misu, MISU, MRT5, RGD1311954, SAKI, TRM4

Protein level used designations for NSUN2

  • Myc-induced SUN domain containing protein
  • NOL1/NOP2/Sun domain family 2
  • myc-induced SUN domain-containing protein
  • tRNA (cytosine(34)-C(5))-methyltransferase
  • tRNA (cytosine-5-)-methyltransferase NSUN2
  • NOL1/NOP2/Sun domain family, member 2
  • NOP2/Sun domain family, member 2
  • 5-methycytoisine methyltransferase
  • Myc-induced SUN-domain-containing protein
  • NOL1/NOP2/Sun domain family member 2
  • hTrm4
  • substrate of AIM1/Aurora kinase B
  • tRNA methyltransferase 4 homolog
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