NR1I3 Products
(Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3))
Categories
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured NR1I3 Categories
NR1I3 Antibodies
High quality antibodies with extensive validation data.
NR1I3 ELISA Kits
Reliable ELISA kits for a wide range of species.
NR1I3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NR1I3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (5)
Cat. No.
ABIN7259546
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7161898
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6263717
Quantity
100 μL
Datasheet
Datasheet
Recommended NR1I3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969015
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969014
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969016
Quantity
96 tests
Datasheet
Datasheet
Recommended NR1I3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312943
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312942
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7418869
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NR1I3 products
: "Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine." in: British journal of pharmacology, Vol. 172, Issue 5, pp. 1263-76, (2015) (PubMed).Synonyms and alternative names related to NR1I3
nuclear receptor subfamily 1 group I member 3 (NR1I3), nuclear receptor subfamily 1, group I, member 3 (Nr1i3), AA209988, AI551208, CAR, CAR-beta, CAR1, Care2, CXR, ESTM32, MB67Protein level used designations for NR1I3
- constitutive androstane receptor
- constitutively transactivates RAREs
- nuclear receptor subfamily 1 group I member 3
- orphan nuclear receptor MB67
- constitutive androstane receptor NR1I3
- nuclear receptor constitutive active receptor
- strain Fischer nuclear receptor (CAR)
- constitutive activator of retinoid response
- constitutive active receptor
- constitutive active response
- constitutive androstane nuclear receptor variant 2
- constitutive androstane nuclear receptor variant 3
- constitutive androstane nuclear receptor variant 4
- constitutive androstane nuclear receptor variant 5
- orphan nuclear hormone receptor
- xenobiotic receptor
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