NR1I2 Products
(Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
Categories
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008].
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Featured NR1I2 Categories
NR1I2 Antibodies
High quality antibodies with extensive validation data.
NR1I2 ELISA Kits
Reliable ELISA kits for a wide range of species.
NR1I2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NR1I2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN738816
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p), IF
Validations
- (5)
Cat. No.
ABIN652618
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (5)
Cat. No.
ABIN5542364
Quantity
100 μL
Datasheet
Datasheet
Recommended NR1I2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958259
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969013
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969012
Quantity
96 tests
Datasheet
Datasheet
Recommended NR1I2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312940
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1787822
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397780
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NR1I2 products
: "Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis." in: Pediatric research, Vol. 83, Issue 5, pp. 1031-1040, (2018) (PubMed).: "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." in: Scientific reports, Vol. 6, pp. 27876, (2016) (PubMed).
: "Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell." in: The international journal of biochemistry & cell biology, Vol. 72, pp. 73-88, (2016) (PubMed).
: "Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays." in: Analytical biochemistry, Vol. 509, pp. 124-9, (2016) (PubMed).
: "St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins." in: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, Vol. 66, Issue 2, pp. 203-14, (2015) (PubMed).
: "Desmethyl bosentan displays a similar in vitro interaction profile as bosentan." in: Pulmonary pharmacology & therapeutics, Vol. 30, pp. 80-6, (2015) (PubMed).
: "3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease." in: Pharmacological research, Vol. 100, pp. 64-72, (2015) (PubMed).
: "Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines." in: The Journal of pharmacy and pharmacology, Vol. 67, Issue 11, pp. 1575-84, (2015) (PubMed).
: "Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats." in: Psychopharmacology, Vol. 231, Issue 17, pp. 3375-90, (2014) (PubMed).
: "Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro." in: Pulmonary pharmacology & therapeutics, Vol. 28, Issue 2, pp. 130-7, (2014) (PubMed).
Synonyms and alternative names related to NR1I2
nuclear receptor subfamily 1 group I member 2 (NR1I2), nuclear receptor subfamily 1, group I, member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 2 S homeolog (nr1i2.S), nuclear receptor subfamily 1, group I, member 2 (nr1i2), BXR, bxr, mPXR, nr1i2, ONR1, onr1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR, xonr1Protein level used designations for NR1I2
- nuclear receptor subfamily 1 group I member 2
- orphan nuclear receptor PAR1
- orphan nuclear receptor PXR
- pregnane X nuclear receptor variant 2
- pregnane X receptor
- steroid and xenobiotic receptor
- Pregnane X receptor
- nuclear receptor subfamily 1, group 1, member 2
- pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
- nuclear receptor subfamily 1 group I member 2 S homeolog
- nuclear receptor subfamily 1, group I, member 2
- orphan nuclear receptor BXR-beta
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