NR1H3 Products
(Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
Categories
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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Featured NR1H3 Categories
NR1H3 Antibodies
High quality antibodies with extensive validation data.
NR1H3 ELISA Kits
Reliable ELISA kits for a wide range of species.
NR1H3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NR1H3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (7)
Cat. No.
ABIN7217836
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Goat, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Xenopus laevis, Zebrafish (Danio rerio)
Application
WB, IHC, IHC (p)
Validations
- (4)
Cat. No.
ABIN462212
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
Cat. No.
ABIN523441
Quantity
100 μg
Datasheet
Datasheet
Recommended NR1H3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958254
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969010
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958253
Quantity
96 tests
Datasheet
Datasheet
Recommended NR1H3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312934
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2727545
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7395752
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NR1H3 products
: "Novel Lactobacillus reuteri HI120 Affects Lipid Metabolism in C57BL/6 Obese Mice." in: Frontiers in veterinary science, Vol. 7, pp. 560241, (2020) (PubMed).: "LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women." in: Breast cancer (Dove Medical Press), Vol. 11, pp. 1-12, (2019) (PubMed).
: "PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells." in: Hepatology communications, Vol. 3, Issue 9, pp. 1191-1204, (2019) (PubMed).
: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." in: The Korean journal of internal medicine, (2018) (PubMed).
: "G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE-/- mice." in: Vascular pharmacology, Vol. 89, pp. 49-57, (2017) (PubMed).
: "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. 8182-7, (2016) (PubMed).
: "AMPK activates LXRα and ABCA1 expression in human macrophages." in: The international journal of biochemistry & cell biology, Vol. 78, pp. 1-9, (2016) (PubMed).
: "Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 35, Issue 4, pp. 1133-44, (2015) (PubMed).
: "Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 503-8, (2014) (PubMed).
: "Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease." in: Digestive diseases and sciences, Vol. 59, Issue 12, pp. 2975-82, (2014) (PubMed).
Synonyms and alternative names related to NR1H3
nuclear receptor subfamily 1 group H member 3 (NR1H3), nuclear receptor subfamily 1 group H member 3 (nr1h3), nuclear receptor subfamily 1, group H, member 3 (Nr1h3), nuclear receptor subfamily 1, group H, member 3 (nr1h3), AU018371, im:7141239, LXR, LXR-a, LXR-alpha, LXRA, LXRalpha, NR1H3, RLD-1, RLD1, Unr1, wu:fd59b01, zgc:113339, zgc:158542Protein level used designations for NR1H3
- nuclear receptor subfamily 1, group H, member 3
- oxysterols receptor LXR-alpha-like
- liver X nuclear receptor alpha variant 1
- oxysterols receptor LXR-alpha
- LXR alpha
- liver X receptor alpha
- ubiquitously-expressed nuclear receptor 1
- nuclear orphan receptor LXR-alpha
- nuclear receptor subfamily 1 group H member 3
- LXRalpha
- liver X receptor
- lxr
- nuclear oxysterol receptor LxR-alpha
- RLD-1
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