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NPTX2 Products

(Neuronal Pentraxin II (NPTX2))

Categories

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009].

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Featured NPTX2 Categories

NPTX2 Antibodies

High quality antibodies with extensive validation data.

NPTX2 ELISA Kits

Reliable ELISA kits for a wide range of species.

NPTX2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NPTX2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN6242482
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN389175
Quantity 400 μL
Datasheet Datasheet

Application WB
Validations
  • (2)
  • (1)
Cat. No. ABIN6746446
Quantity 100 μL
Datasheet Datasheet

Recommended NPTX2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6958131
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958132
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958133
Quantity 96 tests
Datasheet Datasheet

Recommended NPTX2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312904
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7410661
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389926
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our NPTX2 products

Goetzl, Abner, Jicha, Kapogiannis, Schwartz: "Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, Issue 2, pp. 888-893, (2018) (PubMed).

Shukla, Pia Patric, Thinagararjan, Srinivasan, Mondal, Hegde, Chandramouli, Santosh, Arivazhagan, Somasundaram: "A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-κB nexus." in: Cancer research, Vol. 73, Issue 22, pp. 6563-73, (2013) (PubMed).

Moran, Hickey, Michael, Derkacs, Christian, Kalaitzakis, Pearce, Graeber: "Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies." in: Acta neuropathologica, Vol. 115, Issue 4, pp. 471-8, (2008) (PubMed).

Marui, Koishi, Funatogawa, Yamamoto, Matsumoto, Hashimoto, Ishijima, Nanba, Nishida, Sugiyama, Kasai, Watanabe, Kano, Kato, Sasaki: "No association between the neuronal pentraxin II gene polymorphism and autism." in: Progress in neuro-psychopharmacology & biological psychiatry, Vol. 31, Issue 4, pp. 940-3, (2007) (PubMed).

Park, Ryu, Lee, Lee, Yoon, Lee, Yoo, Woo, Lee, Lee, Kim, Yoon: "Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer." in: Pancreas, Vol. 35, Issue 3, pp. e9-15, (2007) (PubMed).

Xu, Hopf, Reddy, Cho, Guo, Lanahan, Petralia, Wenthold, OBrien, Worley: "Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity." in: Neuron, Vol. 39, Issue 3, pp. 513-28, (2003) (PubMed).

Wong, Setou, Teng, Takei, Hirokawa: "Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14500-5, (2002) (PubMed).

Biederer, Südhof: "Mints as adaptors. Direct binding to neurexins and recruitment of munc18." in: The Journal of biological chemistry, Vol. 275, Issue 51, pp. 39803-6, (2001) (PubMed).

Kirkpatrick, Matzuk, Dodds, Perin: "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17786-92, (2000) (PubMed).

Tsui, Copeland, Gilbert, Jenkins, Barnes, Worley: "Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2463-78, (1996) (PubMed).

Synonyms and alternative names related to NPTX2

neuronal pentraxin 2 (NPTX2), neuronal pentraxin 2 (Nptx2), neuronal pentraxin II (NPTX2), neuronal pentraxin 1 (NPTX1), neuronal pentraxin 2a (nptx2a), NARP, Narp, NP-II, NP2, np2, NPTX2, nptx2, p50

Protein level used designations for NPTX2

  • apexin
  • neuronal activity-regulated pentaxin
  • neuronal pentraxin-2
  • NP-II
  • neuro activity regulated petaxin
  • neuronal pentraxin II
  • NP2
  • neuronal activity-regulated pentraxin
  • neuronal pentraxin 2
  • AM50
  • acrosomal pentaxin-like protein p50
  • narp
  • neuronal pentraxin 2a
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