NPR1 Products
(Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))
Categories
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides\; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2\; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009].
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Featured NPR1 Categories
NPR1 Antibodies
High quality antibodies with extensive validation data.
NPR1 ELISA Kits
Reliable ELISA kits for a wide range of species.
NPR1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NPR1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN657994
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC (p)
Validations
- (3)
- (1)
Cat. No.
ABIN392702
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7241978
Quantity
200 μL
Datasheet
Datasheet
Recommended NPR1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968808
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968807
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958039
Quantity
96 tests
Datasheet
Datasheet
Recommended NPR1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124116
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312893
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7491179
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NPR1 products
: "Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes." in: Obesity (Silver Spring, Md.), Vol. 24, Issue 4, pp. 820-8, (2016) (PubMed).: "Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells." in: Cardiovascular research, Vol. 93, Issue 2, pp. 350-9, (2012) (PubMed).
: "Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion." in: Reproduction (Cambridge, England), Vol. 142, Issue 2, pp. 333-43, (2011) (PubMed).
: "The membrane receptors guanylyl cyclase-A and -B undergo distinctive changes in post-translational modification during brain development." in: Journal of neurochemistry, Vol. 115, Issue 4, pp. 1024-34, (2010) (PubMed).
: "Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide." in: The Journal of endocrinology, Vol. 201, Issue 2, pp. 287-95, (2009) (PubMed).
: "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." in: The Journal of comparative neurology, Vol. 516, Issue 1, pp. 36-48, (2009) (PubMed).
: "Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alphaT3-1 and LbetaT2 gonadotroph cells." in: The Journal of endocrinology, Vol. 203, Issue 2, pp. 215-29, (2009) (PubMed).
: "Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina." in: Peptides, Vol. 29, Issue 4, pp. 622-8, (2008) (PubMed).
: "Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 9, pp. 2200-5, (2007) (PubMed).
: "A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion." in: Journal of biomolecular screening, Vol. 12, Issue 6, pp. 865-74, (2007) (PubMed).
Synonyms and alternative names related to NPR1
natriuretic peptide receptor 1 (NPR1), natriuretic peptide receptor 1 (Npr1), natriuretic peptide receptor 1a (npr1a), regulatory protein (NPR1) (NPR1), AI893888, ANPa, ANPRA, Anpra, ARABIDOPSIS NONEXPRESSER OF PR GENES 1, ATNPR1, F15H21.6, F15H21_6, GC-A, Gca, GUC2A, GUCY2A, NIM1, NON-INDUCIBLE IMMUNITY 1, NONEXPRESSER OF PR GENES 1, NPR-A, NPRA, Npra, Pndr, REGULATORY PROTEIN NPR1, SAI1, SALICYLIC ACID INSENSITIVE 1, sGC, si:dkey-27c15.1Protein level used designations for NPR1
- ANP-A
- ANPR-A
- GC-A
- NPR-A
- atrial natriuretic peptide receptor 1
- atrial natriuretic peptide receptor type A
- atrionatriuretic peptide receptor A
- guanylate cyclase A
- natriuretic peptide A type receptor
- natriuretic peptide receptor A
- atrial natriuretic peptide A-type receptor
- atrial natriuretic peptide receptor A
- natriuretic peptide receptor 1
- aatriuretic peptide receptor A
- guanylyl cyclase beta 1, soluable
- natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
- Nppa receptor
- guanylyl cyclase-A
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