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NPC1L1 Proteins

(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

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NPC1L1 Protein (ABIN7491703)

NPC1L1 Origin: Human Host: HEK-293 Cells Synthetic Nanodisc

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NPC1L1 Protein (AA 22-284) (His tag) (ABIN7490787)

NPC1L1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

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NPC1L1 Proteins by Origin

Find NPC1L1 Proteins for a variety of species such as anti-Human NPC1L1. The species listed below are among those available. Click on a link to go to the corresponding products.

NPC1L1 Proteins by Source

Here you will find NPC1L1 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

NPC1L1 Proteins by Protein Type

Here you can find NPC1L1 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Popular NPC1L1 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

NPC1L1 Protein

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7491703

Quantity 100 μg

Datasheet Datasheet

NPC1L1 Protein (AA 22-284) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7490787

Quantity 100 μg

Datasheet Datasheet

Aliases for NPC1L1 Proteins

NPC1 like intracellular cholesterol transporter 1 (NPC1L1) Proteins
NPC1 like 1 (npc1l1) Proteins
NPC1-like 1 (npc1l1) Proteins
NPC1 like intracellular cholesterol transporter 1 (Npc1l1) Proteins
9130221N23Rik Proteins
Gm243 Proteins
NPC1L1 Proteins
NPC11L1 Proteins

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NPC1L1 Proteins by Origin

NPC1L1 Proteins by Source

NPC1L1 Proteins by Protein Type

Popular NPC1L1 Proteins

Aliases for NPC1L1 Proteins

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