NOTCH3 Products
(Notch 3 (NOTCH3))
Categories
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008].
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Featured NOTCH3 Categories
NOTCH3 Antibodies
High quality antibodies with extensive validation data.
NOTCH3 ELISA Kits
Reliable ELISA kits for a wide range of species.
NOTCH3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NOTCH3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (7)
Cat. No.
ABIN7074862
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IF, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN390159
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (3)
Cat. No.
ABIN3023484
Quantity
100 μL
Datasheet
Datasheet
Recommended NOTCH3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968971
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968972
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958226
Quantity
96 tests
Datasheet
Datasheet
Recommended NOTCH3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275361
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275362
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275366
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NOTCH3 products
: "Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes." in: Nature communications, Vol. 10, Issue 1, pp. 2817, (2019) (PubMed).: "Pulmonary pericytes regulate lung morphogenesis." in: Nature communications, Vol. 9, Issue 1, pp. 2448, (2018) (PubMed).
: "Involvement of Notch2 in all‑trans retinoic acid‑induced inhibition of mouse embryonic palate mesenchymal cell proliferation." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 2538-2546, (2017) (PubMed).
: "The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance." in: Pathology oncology research : POR, Vol. 22, Issue 3, pp. 483-92, (2017) (PubMed).
: "The proteins interacting with C-terminal of μ receptor are identified by bacterial two-hybrid system from brain cDNA library in morphine-dependent rats." in: Life sciences, Vol. 143, pp. 156-67, (2016) (PubMed).
: "Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma." in: Pathology oncology research : POR, Vol. 22, Issue 1, pp. 87-94, (2015) (PubMed).
: "Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis." in: Neurobiology of disease, Vol. 75, pp. 131-41, (2015) (PubMed).
: "Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord." in: Journal of cellular and molecular medicine, Vol. 18, Issue 10, pp. 2103-16, (2014) (PubMed).
: "Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 2, pp. 950-60, (2014) (PubMed).
: "Von Willebrand factor inhibits mature smooth muscle gene expression through impairment of Notch signaling." in: PLoS ONE, Vol. 8, Issue 9, pp. e75808, (2013) (PubMed).
Synonyms and alternative names related to NOTCH3
notch 3 (NOTCH3), notch 3 (Notch3), notch 3 (notch3), AW229011, CADASIL, CASIL, fa14b08, hpbk, IMF2, N3, notch5, wu:fa14b08Protein level used designations for NOTCH3
- Notch homolog 3
- neurogenic locus notch homolog protein 3
- Notch gene homolog 3
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