NOTCH2 Products
(Notch 2 (NOTCH2))
Categories
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
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Featured NOTCH2 Categories
NOTCH2 Antibodies
High quality antibodies with extensive validation data.
NOTCH2 ELISA Kits
Reliable ELISA kits for a wide range of species.
NOTCH2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NOTCH2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
- (1)
- (1)
Cat. No.
ABIN104899
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN3181821
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ChIP-seq
Validations
- (1)
- (2)
Cat. No.
ABIN2854343
Quantity
100 μL
Datasheet
Datasheet
Recommended NOTCH2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968970
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968969
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958224
Quantity
96 tests
Datasheet
Datasheet
Recommended NOTCH2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275365
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7013569
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
CHO Cells
Validations
- (1)
Cat. No.
ABIN1344244
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our NOTCH2 products
: "Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway." in: Scientific reports, Vol. 10, Issue 1, pp. 5708, (2020) (PubMed).: "Protein Expression Analysis in Uterine Cervical Cancer for Potential Targets in Treatment." in: Pathology oncology research : POR, (2018) (PubMed).
: "Epistatic Association of CD14 and NOTCH2 Genetic Polymorphisms with Biliary Atresia in a Southern Chinese Population." in: Molecular therapy. Nucleic acids, Vol. 13, pp. 590-595, (2018) (PubMed).
: "NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells." in: Oncology reports, Vol. 34, Issue 4, pp. 1650-8, (2015) (PubMed).
: "RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45." in: The Journal of biological chemistry, Vol. 289, Issue 30, pp. 21163-80, (2015) (PubMed).
: "Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice." in: PLoS ONE, Vol. 9, Issue 5, pp. e96253, (2015) (PubMed).
: "Interference of Notch 2 inhibits the progression of gliomas and induces cell apoptosis by induction of the cell cycle at the G0/G1 phase." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 734-8, (2014) (PubMed).
: "Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo." in: Molecular medicine reports, Vol. 10, Issue 6, pp. 2843-50, (2014) (PubMed).
: "Macrophage-derived delta-like protein 1 enhances interleukin-6 and matrix metalloproteinase 3 production by fibroblast-like synoviocytes in mice with collagen-induced arthritis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 66, Issue 10, pp. 2751-61, (2014) (PubMed).
: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).
Synonyms and alternative names related to NOTCH2
neurogenic locus notch homolog protein 2 (LOC581186), notch 2 (NOTCH2), notch 3 (notch3), notch 2 (Notch2), notch 2 (notch2), AGS2, AI853703, HJCYS, hN2, N2, notch6, sb:cb884Protein level used designations for NOTCH2
- notch 2
- neurogenic locus notch homolog protein 2-like
- Notch homolog 2
- neurogenic locus notch homolog protein 2
- Motch B
- Notch gene homolog 2
- notch gene homolog 2
- notch receptor protein 6
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