Notch1 Products
(Notch 1 (NOTCH1))
Categories
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008].
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Featured Notch1 Categories
Notch1 Antibodies
High quality antibodies with extensive validation data.
Notch1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Notch1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Notch1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
FACS
Validations
- (6)
- (4)
Cat. No.
ABIN807924
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
FACS
Validations
- (6)
- (4)
Cat. No.
ABIN2749161
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN675114
Quantity
100 μL
Datasheet
Datasheet
Recommended Notch1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958221
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958222
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958223
Quantity
96 tests
Datasheet
Datasheet
Recommended Notch1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275363
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275364
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
CHO Cells
Validations
- (1)
Cat. No.
ABIN1344230
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Notch1 products
: "Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway." in: Scientific reports, Vol. 10, Issue 1, pp. 5708, (2020) (PubMed).: "Altered expression of Notch1 in Alzheimer's disease." in: PLoS ONE, Vol. 14, Issue 11, pp. e0224941, (2020) (PubMed).
: "Enhanced lysosomal degradation maintains the quiescent state of neural stem cells." in: Nature communications, Vol. 10, Issue 1, pp. 5446, (2019) (PubMed).
: "Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling." in: Cell stem cell, Vol. 23, Issue 4, pp. 530-543.e9, (2018) (PubMed).
: "Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations." in: Scientific reports, Vol. 8, Issue 1, pp. 17987, (2018) (PubMed).
: "Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases." in: Clinical oral investigations, (2017) (PubMed).
: "NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis." in: Stem cells (Dayton, Ohio), Vol. 35, Issue 4, pp. 1106-1119, (2017) (PubMed).
: "Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning." in: Developmental cell, Vol. 40, Issue 5, pp. 505-511.e6, (2017) (PubMed).
: "Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1." in: The Journal of biological chemistry, Vol. 292, Issue 2, pp. 732-747, (2017) (PubMed).
: "Chlamydia and ocular adnexal lymphomas: An Indian experience." in: Experimental and molecular pathology, Vol. 101, Issue 1, pp. 74-80, (2016) (PubMed).
Synonyms and alternative names related to Notch1
notch 1 (notch1), fibropellin-1 (LOC100631526), Notch homolog 1, translocation-associated (Drosophila) (NOTCH1), notch 1 (NOTCH1), Notch homolog 1, translocation-associated (NOTCH1), notch 1 (Notch1), notch 1 S homeolog (notch1.S), 9930111A19Rik, hn1, hN1, lin-12, Mis6, N1, notch, NOTCH, notch-1, notch1, NOTCH1, notch1-a, tan1, TAN1, Tan1, xnotch, xnotch1, xotch, XotchProtein level used designations for Notch1
- notch 1
- Notch homolog 1, translocation-associated (Drosophila)
- Notch homolog 1, translocation-associated
- neurogenic locus notch homolog protein 1
- translocation-associated notch protein TAN-1
- Motch A
- Notch gene homolog 1
- mT14
- major type A protein
- p300
- transmembrane receptor Notch1
- Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
- neurogenic locus notch protein homolog
- NOTCH-1
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