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Notch1 Products

(Notch 1 (NOTCH1))
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008].

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Featured Notch1 Categories

Notch1 Antibodies

High quality antibodies with extensive validation data.

Notch1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Notch1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Notch1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application FACS
Validations
  • (6)
  • (4)
Cat. No. ABIN807924
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application FACS
Validations
  • (6)
  • (4)
Cat. No. ABIN2749161
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (2)
Cat. No. ABIN675114
Quantity 100 μL
Datasheet Datasheet

Recommended Notch1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958221
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958222
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958223
Quantity 96 tests
Datasheet Datasheet

Recommended Notch1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275363
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275364
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source CHO Cells
Validations
  • (1)
Cat. No. ABIN1344230
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Notch1 products

Iervolino, Prosperi, De La Motte, Petrillo, Spagnuolo, DAcierno, Siccardi, Perna, Christensen, Frische, Capasso, Trepiccione: "Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway." in: Scientific reports, Vol. 10, Issue 1, pp. 5708, (2020) (PubMed).

Cho, Yun, Jo, Jeong, Park, Han, Koh: "Altered expression of Notch1 in Alzheimer's disease." in: PLoS ONE, Vol. 14, Issue 11, pp. e0224941, (2020) (PubMed).

Kobayashi, Piao, Takamura, Kori, Miyachi, Kitano, Iwamoto, Yamada, Imayoshi, Shioda, Ballabio, Kageyama: "Enhanced lysosomal degradation maintains the quiescent state of neural stem cells." in: Nature communications, Vol. 10, Issue 1, pp. 5446, (2019) (PubMed).

Verma, Asakura, Murakonda, Pengo, Latroche, Chazaud, McLoon, Asakura: "Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling." in: Cell stem cell, Vol. 23, Issue 4, pp. 530-543.e9, (2018) (PubMed).

Davis, Pahl, Datto, Smith, Shawber, Caron, Blatt: "Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations." in: Scientific reports, Vol. 8, Issue 1, pp. 17987, (2018) (PubMed).

Wang, Fan, Xu, Zhao: "Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases." in: Clinical oral investigations, (2017) (PubMed).

Hrstka, Li, Nelson: "NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis." in: Stem cells (Dayton, Ohio), Vol. 35, Issue 4, pp. 1106-1119, (2017) (PubMed).

Shaya, Binshtok, Hersch, Rivkin, Weinreb, Amir-Zilberstein, Khamaisi, Oppenheim, Desai, Goodyear, Richardson, Chen, Sprinzak: "Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning." in: Developmental cell, Vol. 40, Issue 5, pp. 505-511.e6, (2017) (PubMed).

Lee, Khan, Khaliqdina, Altintas, Grahammer, Zhao, Koh, Tardi, Faridi, Geraghty, Cimbaluk, Susztak, Moita, Baltimore, Tharaux, Huber, Kretzler, Bitzer, Reiser, Gupta: "Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1." in: The Journal of biological chemistry, Vol. 292, Issue 2, pp. 732-747, (2017) (PubMed).

Bhardwaj, Sharma, Sen, Kumar, Satpathy, Kashyap, Pushker, Singh, Rai: "Chlamydia and ocular adnexal lymphomas: An Indian experience." in: Experimental and molecular pathology, Vol. 101, Issue 1, pp. 74-80, (2016) (PubMed).

Synonyms and alternative names related to Notch1

notch 1 (notch1), fibropellin-1 (LOC100631526), Notch homolog 1, translocation-associated (Drosophila) (NOTCH1), notch 1 (NOTCH1), Notch homolog 1, translocation-associated (NOTCH1), notch 1 (Notch1), notch 1 S homeolog (notch1.S), 9930111A19Rik, hn1, hN1, lin-12, Mis6, N1, notch, NOTCH, notch-1, notch1, NOTCH1, notch1-a, tan1, TAN1, Tan1, xnotch, xnotch1, xotch, Xotch

Protein level used designations for Notch1

  • notch 1
  • Notch homolog 1, translocation-associated (Drosophila)
  • Notch homolog 1, translocation-associated
  • neurogenic locus notch homolog protein 1
  • translocation-associated notch protein TAN-1
  • Motch A
  • Notch gene homolog 1
  • mT14
  • major type A protein
  • p300
  • transmembrane receptor Notch1
  • Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
  • neurogenic locus notch protein homolog
  • NOTCH-1
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