NOD2 Products
(Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
Categories
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq, Jul 2008].
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Featured NOD2 Categories
NOD2 Antibodies
High quality antibodies with extensive validation data.
NOD2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended NOD2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7269065
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6263679
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7162073
Quantity
100 μg
Datasheet
Datasheet
Recommended NOD2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969034
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958283
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975077
Quantity
96 tests
Datasheet
Datasheet
Recommended NOD2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094134
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136591
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NOD2 products
: "Nicotine modulates molecules of the innate immune response in epithelial cells and macrophages during infection with M. tuberculosis." in: Clinical and experimental immunology, Vol. 199, Issue 2, pp. 230-243, (2020) (PubMed).: "The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 48, Issue 1, pp. 87-95, (2019) (PubMed).
: "Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation." in: Glia, Vol. 66, Issue 11, pp. 2427-2437, (2019) (PubMed).
: "NOD1 and NOD2 of the innate immune system is differently expressed in human clear cell renal cell carcinoma, corresponding healthy renal tissue, its vasculature and primary isolated renal tubular ..." in: Journal of cancer research and clinical oncology, Vol. 145, Issue 6, pp. 1405-1416, (2019) (PubMed).
: "Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2. ..." in: Cold Spring Harbor molecular case studies, Vol. 5, Issue 1, (2019) (PubMed).
: "Vitamin D Promotes Pneumococcal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils." in: Journal of innate immunity, (2017) (PubMed).
: "Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication." in: PLoS ONE, Vol. 9, Issue 3, pp. e92704, (2014) (PubMed).
: "NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells." in: Inflammatory bowel diseases, Vol. 20, Issue 1, pp. 126-35, (2013) (PubMed).
: "NOD1 and NOD2 regulate proinflammatory and prolabor mediators in human fetal membranes and myometrium via nuclear factor-kappa B." in: Biology of reproduction, Vol. 89, Issue 1, pp. 14, (2013) (PubMed).
: "RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 52, pp. 21426-31, (2012) (PubMed).
Synonyms and alternative names related to NOD2
caspase recruitment domain 15 protein (TTHERM_01951320), nucleotide binding oligomerization domain containing 2 (NOD2), nucleotide-binding oligomerization domain containing 2 (Nod2), ACUG, BLAU, CARD15, Card15, CD, CLR16.3, F830032C23Rik, IBD1, NLRC2, Nlrc2, NOD2B, PSORAS1Protein level used designations for NOD2
- caspase recruitment domain 15 protein
- NLR family, CARD domain containing 2
- NOD-like receptor C2
- caspase recruitment domain family, member 15
- caspase recruitment domain protein 15
- caspase recruitment domain-containing protein 15
- inflammatory bowel disease protein 1
- nucleotide-binding oligomerization domain 2
- nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
- nucleotide-binding oligomerization domain-containing protein 2
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