NOD1 Products
(Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))
Categories
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009].
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Featured NOD1 Categories
NOD1 Antibodies
High quality antibodies with extensive validation data.
NOD1 ELISA Kits
Reliable ELISA kits for a wide range of species.
NOD1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NOD1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN3021838
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC (p), ICC
Validations
- (6)
Cat. No.
ABIN3032080
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (3)
Cat. No.
ABIN872332
Quantity
100 μL
Datasheet
Datasheet
Recommended NOD1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6974816
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1145825
Quantity
96 tests
Datasheet
Datasheet
Recommended NOD1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312761
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312757
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312759
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our NOD1 products
: "Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway." in: International journal of molecular sciences, Vol. 19, Issue 11, (2019) (PubMed).: "Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity." in: BioMed research international, Vol. 2016, pp. 9325436, (2016) (PubMed).
: "Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses." in: Cancer research, Vol. 76, Issue 5, pp. 1135-45, (2016) (PubMed).
: "The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior." in: Molecular psychiatry, Vol. 22, Issue 2, pp. 257-266, (2016) (PubMed).
: "Proteasome particle-rich structures are widely present in human epithelial neoplasms: correlative light, confocal and electron microscopy study." in: PLoS ONE, Vol. 6, Issue 6, pp. e21317, (2011) (PubMed).
: "Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production." in: Journal of hepatology, Vol. 53, Issue 4, pp. 693-701, (2010) (PubMed).
: "Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis." in: World journal of gastroenterology, Vol. 16, Issue 34, pp. 4348-56, (2010) (PubMed).
: "Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 24, pp. 11056-61, (2010) (PubMed).
: "Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation." in: Molecular human reproduction, Vol. 15, Issue 5, pp. 311-9, (2009) (PubMed).
: "Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 5, pp. 536-42, (2008) (PubMed).
Synonyms and alternative names related to NOD1
nucleotide binding oligomerization domain containing 1 (NOD1), nucleotide-binding oligomerization domain containing 1 (Nod1), C230079P11, CARD4, Card4, CLR7.1, F830007N14Rik, NLRC1, Nlrc1, RGD1562269Protein level used designations for NOD1
- NLR family, CARD domain containing 1
- caspase recruitment domain family, member 4
- caspase recruitment domain-containing protein 4
- nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1
- nucleotide-binding oligomerization domain-containing protein 1
- caspase recruitment domain 4
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