NLRP3 Products
(NLR Family, Pyrin Domain Containing 3 (NLRP3))
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This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008].
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Featured NLRP3 Categories
NLRP3 Antibodies
High quality antibodies with extensive validation data.
NLRP3 ELISA Kits
Reliable ELISA kits for a wide range of species.
NLRP3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NLRP3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IF, IP
Validations
- (60)
- (5)
Cat. No.
ABIN1169100
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Dog, Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IF (p), ICC, IF (cc), IHC (fro)
Validations
- (11)
- (15)
Cat. No.
ABIN1386361
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7443710
Quantity
100 μL
Datasheet
Datasheet
Recommended NLRP3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971279
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958210
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958211
Quantity
96 tests
Datasheet
Datasheet
Recommended NLRP3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (5)
- (1)
Cat. No.
ABIN1312675
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124184
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312677
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our NLRP3 products
: "Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation." in: Microbiology spectrum, Vol. 9, Issue 2, pp. e0073021, (2022) (PubMed).: "XIST Inhibition Attenuates Calcium Oxalate Nephrocalcinosis-Induced Renal Inflammation and Oxidative Injury via the miR-223/NLRP3 Pathway." in: Oxidative medicine and cellular longevity, Vol. 2021, pp. 1676152, (2022) (PubMed).
: "Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway." in: Nutrients, Vol. 12, Issue 5, (2021) (PubMed).
: "P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages." in: Cell death & disease, Vol. 11, Issue 5, pp. 394, (2021) (PubMed).
: "Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease." in: Frontiers in aging neuroscience, Vol. 13, pp. 629891, (2021) (PubMed).
: "Roseburia intestinalis‑derived flagellin ameliorates colitis by targeting miR‑223‑3p‑mediated activation of NLRP3 inflammasome and pyroptosis." in: Molecular medicine reports, Vol. 22, Issue 4, pp. 2695-2704, (2021) (PubMed).
: "NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis." in: Nature communications, Vol. 10, Issue 1, pp. 4375, (2020) (PubMed).
: "LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression." in: Bioscience reports, Vol. 40, Issue 8, (2020) (PubMed).
: "25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner." in: Journal of neuroinflammation, Vol. 17, Issue 1, pp. 192, (2020) (PubMed).
: "Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture." in: Immunology, Vol. 161, Issue 1, pp. 39-52, (2020) (PubMed).
Synonyms and alternative names related to NLRP3
NLR family pyrin domain containing-like (NLRPL), NLR family pyrin domain containing 3 (NLRP3), NLR family, pyrin domain containing 3 L homeolog (nlrp3.L), NLR family, pyrin domain containing 3 (Nlrp3), agtavprl, AGTAVPRL, AII, AII/AVP, avp, AVP, C1orf7, CIAS1, cias1, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, Nalp3, nalp3, NALP3, pypaf1, PYPAF1, Pypaf1Protein level used designations for NLRP3
- NACHT, LRR and PYD domains-containing protein 3
- cold autoinflammatory syndrome 1
- cryopyrin
- NLR family, pyrin domain containing 3
- NACHT, LRR and PYD domains-containing protein 3-like
- NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
- NACHT, LRR and PYD containing protein 3
- PYRIN-containing APAF1-like protein 1
- caterpiller protein 1.1
- cold autoinflammatory syndrome 1 protein
- nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
- NACHT/LRR/pyrin domain-containing protein 3
- cold autoinflammatory syndrome 1 homolog
- cold autoinflammatory syndrome 1 protein homolog
- mast cell maturation inducible protein 1
- mast cell maturation-associated-inducible protein 1
- NLR family pyrin domain containing 3
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