NLRC4 Products
(NLR Family, CARD Domain Containing 4 (NLRC4))
Categories
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008].
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Featured NLRC4 Categories
NLRC4 Antibodies
High quality antibodies with extensive validation data.
NLRC4 ELISA Kits
Reliable ELISA kits for a wide range of species.
NLRC4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NLRC4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
IHC, IF
Validations
- (5)
Cat. No.
ABIN7008065
Quantity
60 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, ICC
Validations
- (4)
Cat. No.
ABIN5611209
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN6144657
Quantity
100 μL
Datasheet
Datasheet
Recommended NLRC4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968953
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962707
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958209
Quantity
96 tests
Datasheet
Datasheet
Recommended NLRC4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124183
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312662
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094174
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NLRC4 products
: "Iraqi propolis increases degradation of IL-1β and NLRC4 by autophagy following Pseudomonas aeruginosa infection." in: Microbes and infection, Vol. 20, Issue 2, pp. 89-100, (2018) (PubMed).: "Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121525, (2015) (PubMed).
: "Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation." in: American journal of physiology. Renal physiology, Vol. 306, Issue 3, pp. F299-308, (2014) (PubMed).
: "Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization." in: Immunity, Vol. 37, Issue 1, pp. 35-47, (2012) (PubMed).
: "A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif." in: Nature cell biology, Vol. 2, Issue 12, pp. 915-21, (2001) (PubMed).
: "Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2." in: Gene, Vol. 261, Issue 2, pp. 197-203, (2001) (PubMed).
: "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1." in: The Journal of biological chemistry, Vol. 276, Issue 30, pp. 28309-13, (2001) (PubMed).
: "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis." in: Biochemical and biophysical research communications, Vol. 284, Issue 1, pp. 77-82, (2001) (PubMed).
: "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis." in: Science (New York, N.Y.), Vol. 293, Issue 5536, pp. 1829-32, (2001) (PubMed).
: "Apoptosis. Till death us do part." in: Science (New York, N.Y.), Vol. 293, Issue 5536, pp. 1784-5, (2001) (PubMed).
Synonyms and alternative names related to NLRC4
NLR family CARD domain containing 4 (NLRC4), NLR family, CARD domain containing 4 (Nlrc4), 9530011P19Rik, CARD12, Card12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAFProtein level used designations for NLRC4
- caspase recruitment domain protein 12
- NLR family CARD domain-containing protein 4
- ice protease-activating factor
- ipaf
- NLR family, CARD domain containing 4
- CARD, LRR, and NACHT-containing protein
- ICE-protease activating factor
- NOD-like receptor C4
- caspase recruitment domain family, member 12
- caspase recruitment domain-containing protein 12
- nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
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