NLK.2 Proteins
(Nemo-Like Kinase, Gene 2 (NLK.2))
Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 to phosphorylate stat3.1. Augments the rnf138/narf-directed ubiquitination and degradation of tcf/lef by enhancing the association of rnf138/narf and tcf/lef. Phosphorylates mef2a to play a role in anterior neural development, including eye formation.
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Recommended NLK.2 Proteins
Synonyms and alternative names related to NLK.2
nemo-like kinase, gene 2 S homeolog (nlk.2.S), nlk, xnlkProtein level used designations for NLK.2
- Nemo-like kinase 2
- Serine/threonine protein kinase NLK2
- serine/threonine-protein kinase NLK2
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