Nischarin Products
(Nischarin (NISCH))
Categories
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis\; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].
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Featured Nischarin Categories
Nischarin Antibodies
High quality antibodies with extensive validation data.
Nischarin ELISA Kits
Reliable ELISA kits for a wide range of species.
Nischarin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Nischarin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7161622
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN524609
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC
Validations
- (3)
Cat. No.
ABIN1869472
Quantity
100 μL
Datasheet
Datasheet
Recommended Nischarin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958198
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1145172
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1145173
Quantity
96 tests
Datasheet
Datasheet
Recommended Nischarin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312597
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7389638
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7415323
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Nischarin products
: "Expression of integrin-binding protein Nischarin in metastatic breast cancer." in: Molecular medicine reports, Vol. 12, Issue 1, pp. 77-82, (2015) (PubMed).: "A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin." in: The Biochemical journal, Vol. 377, Issue Pt 2, pp. 449-57, (2004) (PubMed).
: "The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK." in: The EMBO journal, Vol. 23, Issue 14, pp. 2777-88, (2004) (PubMed).
: "Integrin regulation of cell signalling and motility." in: Biochemical Society transactions, Vol. 32, Issue Pt3, pp. 443-6, (2004) (PubMed).
: "Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK." in: Experimental cell research, Vol. 288, Issue 2, pp. 415-24, (2003) (PubMed).
: "Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration." in: The Journal of cell biology, Vol. 151, Issue 6, pp. 1141-54, (2001) (PubMed).
Synonyms and alternative names related to Nischarin
nischarin (NISCH), nischarin (Cyan7822_6841), nischarin S homeolog (nisch.S), nischarin (nisch), nischarin (Nisch), 1200007D05Rik, 3202002H23Rik, AW494485, hIRAS, I-1, IR1, IRAS, NISCHProtein level used designations for Nischarin
- nischarin
- nischarin-like
- I1R
- IR1
- imidazoline receptor 1
- imidazoline receptor I-1-like protein
- imidazoline-1 receptor
- I-1 receptor candidate protein
- imidazoline receptor I-1
- I1R candidate protein
- imidazoline receptor antisera selected
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