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NIPBL Products

(Nipped-B like Protein (NIPBL))

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This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured NIPBL Categories

NIPBL Antibodies

High quality antibodies with extensive validation data.

NIPBL Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NIPBL Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
  • (1)
Cat. No. ABIN1714202
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN570861
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (2)
Cat. No. ABIN7161618
Quantity 100 μg
Datasheet Datasheet

Recommended NIPBL ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6205160
Quantity 96 tests
Datasheet Datasheet

Recommended NIPBL Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312586
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312588
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our NIPBL products

Mazzola, Deflorian, Pezzotta, Ferrari, Fazio, Bresciani, Saitta, Ferrari, Fumagalli, Parma, Marasca, Bodega, Riva, Cotelli, Biondi, Marozzi, Cazzaniga, Pistocchi: "NIPBL: a new player in myeloid cell differentiation." in: Haematologica, Vol. 104, Issue 7, pp. 1332-1341, (2019) (PubMed).

Xu, Ying, Shan, Feng, Zhang, Gao, Xu, Yao, Zhu, Mao: "Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer." in: Journal of translational medicine, Vol. 13, pp. 153, (2015) (PubMed).

Liu, Zhang, Bando, Itoh, Deardorff, Clark, Kaur, Tandy, Kondoh, Rappaport, Spinner, Vega, Jackson, Shirahige, Krantz: "Transcriptional dysregulation in NIPBL and cohesin mutant human cells." in: PLoS biology, Vol. 7, Issue 5, pp. e1000119, (2009) (PubMed).

Seitan, Banks, Laval, Majid, Dorsett, Rana, Smith, Bateman, Krpic, Hostert, Rollins, Erdjument-Bromage, Tempst, Benard, Hekimi, Newbury, Strachan: "Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance." in: PLoS biology, Vol. 4, Issue 8, pp. e242, (2006) (PubMed).

Synonyms and alternative names related to NIPBL

NIPBL, cohesin loading factor (NIPBL), Nipped-B homolog-like (NIPBLL), NIPBL, cohesin loading factor S homeolog (nipbl.S), Nipped-B homolog-like (LOC427439), nipped-B homolog b (Drosophila) (nipblb), nipped-B-like protein A (LOC100164947), NIPBL, cohesin loading factor (nipbl), Nipped-B homolog (Drosophila) (Nipbl), NIPBL, cohesin loading factor (Nipbl), 4921518A06Rik, 4933421G18Rik, C79399, CDLS, CDLS1, IDN3, Idn3, IDN3-B, nipbl, NIPBL, nipbla, Scc2, scc2, scc2-2, SCC2W, wu:fi33d08

Protein level used designations for NIPBL

  • SCC2 homolog
  • delangin
  • nipped-B-like protein
  • sister chromatid cohesion 2 homolog
  • Nipped-B homolog
  • Scc2-2A
  • Scc2-2B
  • sister chromatid cohesion establishment factor 2
  • Nipped-B homolog (Drosophila)
  • nipped-B like a
  • nipped-B-like protein B
  • nipped-B-like protein-like
  • delangin homolog
  • LOW QUALITY PROTEIN: nipped-B-like protein
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