NIPBL Products
(Nipped-B like Protein (NIPBL))
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This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured NIPBL Categories
NIPBL Antibodies
High quality antibodies with extensive validation data.
NIPBL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NIPBL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (1)
Cat. No.
ABIN1714202
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN570861
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN7161618
Quantity
100 μg
Datasheet
Datasheet
Recommended NIPBL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6205160
Quantity
96 tests
Datasheet
Datasheet
Recommended NIPBL Proteins
Latest Publications for our NIPBL products
: "NIPBL: a new player in myeloid cell differentiation." in: Haematologica, Vol. 104, Issue 7, pp. 1332-1341, (2019) (PubMed).: "Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer." in: Journal of translational medicine, Vol. 13, pp. 153, (2015) (PubMed).
: "Transcriptional dysregulation in NIPBL and cohesin mutant human cells." in: PLoS biology, Vol. 7, Issue 5, pp. e1000119, (2009) (PubMed).
: "Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance." in: PLoS biology, Vol. 4, Issue 8, pp. e242, (2006) (PubMed).
Synonyms and alternative names related to NIPBL
NIPBL, cohesin loading factor (NIPBL), Nipped-B homolog-like (NIPBLL), NIPBL, cohesin loading factor S homeolog (nipbl.S), Nipped-B homolog-like (LOC427439), nipped-B homolog b (Drosophila) (nipblb), nipped-B-like protein A (LOC100164947), NIPBL, cohesin loading factor (nipbl), Nipped-B homolog (Drosophila) (Nipbl), NIPBL, cohesin loading factor (Nipbl), 4921518A06Rik, 4933421G18Rik, C79399, CDLS, CDLS1, IDN3, Idn3, IDN3-B, nipbl, NIPBL, nipbla, Scc2, scc2, scc2-2, SCC2W, wu:fi33d08Protein level used designations for NIPBL
- SCC2 homolog
- delangin
- nipped-B-like protein
- sister chromatid cohesion 2 homolog
- Nipped-B homolog
- Scc2-2A
- Scc2-2B
- sister chromatid cohesion establishment factor 2
- Nipped-B homolog (Drosophila)
- nipped-B like a
- nipped-B-like protein B
- nipped-B-like protein-like
- delangin homolog
- LOW QUALITY PROTEIN: nipped-B-like protein
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