Nicastrin Products
(Nicastrin (NCSTN))
Categories
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Featured Nicastrin Categories
Nicastrin Antibodies
High quality antibodies with extensive validation data.
Nicastrin ELISA Kits
Reliable ELISA kits for a wide range of species.
Nicastrin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Nicastrin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN565059
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN7268905
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (1)
- (1)
Cat. No.
ABIN761801
Quantity
100 μL
Datasheet
Datasheet
Recommended Nicastrin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4883865
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730247
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1145111
Quantity
96 tests
Datasheet
Datasheet
Recommended Nicastrin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312150
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312152
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320108
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Nicastrin products
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).
: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." in: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).
Synonyms and alternative names related to Nicastrin
nicastrin (NCSTN), nicastrin (nct), nicastrin (ncstn), nicastrin (CpipJ_CPIJ001617), nicastrin (Ncstn), Nicastrin (aph-2), 9430068N19Rik, AA727311, agro, APH2, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, Nic, nic, S5A, ST96BProtein level used designations for Nicastrin
- CG7012-PA
- CG7012-PC
- CG7012-PD
- CG7012-PE
- agoraphobic
- dNicastrin
- nct-PA
- nct-PC
- nct-PD
- nct-PE
- nicastrin
- ATAG1874
- anterior pharynx-defective 2
- membrane protein
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