Nibrin Products
(Nibrin (NBN))
Categories
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008].
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Featured Nibrin Categories
Nibrin Antibodies
High quality antibodies with extensive validation data.
Nibrin ELISA Kits
Reliable ELISA kits for a wide range of species.
Nibrin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Nibrin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (8)
Cat. No.
ABIN1724946
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (8)
Cat. No.
ABIN1724942
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (9)
Cat. No.
ABIN1491539
Quantity
100 μL
Datasheet
Datasheet
Recommended Nibrin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380647
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380503
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1145103
Quantity
96 tests
Datasheet
Datasheet
Recommended Nibrin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312044
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1989706
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396661
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Nibrin products
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." in: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).
: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." in: Familial cancer, Vol. 11, Issue 4, pp. 595-600, (2012) (PubMed).
: "Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells." in: Cancer prevention research (Philadelphia, Pa.), Vol. 4, Issue 12, pp. 1973-81, (2011) (PubMed).
: "Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma." in: Molecular carcinogenesis, Vol. 50, Issue 9, pp. 689-96, (2011) (PubMed).
: "Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia." in: Cerebellum (London, England), Vol. 8, Issue 1, pp. 22-7, (2009) (PubMed).
: "Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 42, pp. 16165-70, (2008) (PubMed).
: "Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells." in: Cancer research, Vol. 67, Issue 4, pp. 1513-9, (2007) (PubMed).
: "Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype." in: Cancer research, Vol. 66, Issue 6, pp. 2907-12, (2006) (PubMed).
: "Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition." in: Cancer research, Vol. 66, Issue 16, pp. 8109-15, (2006) (PubMed).
Synonyms and alternative names related to Nibrin
nibrin (NBN), nibrin (nbn), nibrin (Nbn), AT-V1, AT-V2, ATV, im:6911679, NBN, NBS, NBS1, Nbs1, P95, zgc:194152Protein level used designations for Nibrin
- nibrin
- Nijmegen breakage syndrome 1 (nibrin)
- cell cycle regulatory protein p95
- p95 protein of the MRE11/RAD50 complex
- nijmegen breakage syndrome protein 1 homolog
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