NHEJ1 Products
(Nonhomologous End-Joining Factor 1 (NHEJ1))
Categories
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008].
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Featured NHEJ1 Categories
NHEJ1 Antibodies
High quality antibodies with extensive validation data.
NHEJ1 ELISA Kits
Reliable ELISA kits for a wide range of species.
NHEJ1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NHEJ1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey
Application
WB, IF, IHC, FACS, IHC (p)
Validations
- (15)
Cat. No.
ABIN1499728
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, IHC
Validations
- (5)
Cat. No.
ABIN7261171
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (4)
Cat. No.
ABIN2857060
Quantity
100 μL
Datasheet
Datasheet
Recommended NHEJ1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1145258
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1145259
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1145260
Quantity
96 tests
Datasheet
Datasheet
Recommended NHEJ1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312543
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN6387017
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130830
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our NHEJ1 products
: "PHF6 promotes non-homologous end joining and G2 checkpoint recovery." in: EMBO reports, Vol. 21, Issue 1, pp. e48460, (2020) (PubMed).: "XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining." in: Nature structural & molecular biology, Vol. 25, Issue 10, pp. 971-980, (2018) (PubMed).
: "PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF." in: Cell reports, Vol. 17, Issue 2, pp. 541-555, (2016) (PubMed).
: "Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 20, pp. E2575-84, (2015) (PubMed).
: "C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin." in: Biochemical and biophysical research communications, Vol. 439, Issue 2, pp. 173-8, (2013) (PubMed).
: "Clinical variability and novel mutations in the NHEJ1 gene in patients with a Nijmegen breakage syndrome-like phenotype." in: Human mutation, Vol. 31, Issue 9, pp. 1059-68, (2010) (PubMed).
: "Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 11, pp. 4518-23, (2007) (PubMed).
: "Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell." in: The Journal of biological chemistry, Vol. 282, Issue 44, pp. 31937-43, (2007) (PubMed).
: "XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining." in: Cell, Vol. 124, Issue 2, pp. 301-13, (2006) (PubMed).
Synonyms and alternative names related to NHEJ1
non-homologous end joining factor 1 (NHEJ1), non-homologous end joining factor 1 S homeolog (nhej1.S), non-homologous end joining factor 1 (nhej1), solute carrier family 23 member 3 (SLC23A3), nonhomologous end-joining factor 1 (nhej1), nonhomologous end-joining factor 1 (Nhej1), 1700029B21Rik, cernunnos, NHEJ1, XLF, zgc:85657Protein level used designations for NHEJ1
- nonhomologous end-joining factor 1
- non-homologous end-joining factor 1
- XRCC4-like factor
- protein cernunnos
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