NFkB Products
(Nuclear Factor kappa B (NFkB))
Categories
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
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Featured NFkB Categories
NFkB Antibodies
High quality antibodies with extensive validation data.
NFkB ELISA Kits
Reliable ELISA kits for a wide range of species.
NFkB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NFkB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7434137
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7442525
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7434143
Quantity
100 μL
Datasheet
Datasheet
Recommended NFkB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (8)
- (5)
Cat. No.
ABIN6730872
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (26)
- (1)
Cat. No.
ABIN6958236
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6958235
Quantity
96 tests
Datasheet
Datasheet
Recommended NFkB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7415128
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394927
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7421872
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NFkB products
: "Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits." in: , Vol. 2022, pp. 2863023, (2022) (PubMed).: "Na+/K+-ATPase Alpha 2 Isoform Elicits Rac1-Dependent Oxidative Stress and TLR4-Induced Inflammation in the Hypothalamic Paraventricular Nucleus in High Salt-Induced Hypertension." in: Antioxidants (Basel, Switzerland), Vol. 11, Issue 2, (2022) (PubMed).
: "Anti-breast Cancer Activity of SPG-56 from Sweet Potato in MCF-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis." in: Scientific reports, Vol. 9, Issue 1, pp. 146, (2020) (PubMed).
: "Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells." in: Journal of biochemical and molecular toxicology, Vol. 34, Issue 2, pp. e22433, (2020) (PubMed).
: "New insights into the protection of growth hormone in cisplatin-induced nephrotoxicity: The impact of IGF-1 on the Keap1-Nrf2/HO-1 signaling." in: Life sciences, Vol. 253, pp. 117581, (2020) (PubMed).
: "UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl3-induced neurotoxicity in rats." in: Journal of ethnopharmacology, Vol. 259, pp. 112930, (2020) (PubMed).
: "The shear wave elastic modulus and the increased nuclear factor kappa B (NF-kB/p65) and cyclooxygenase-2 (COX-2) expression in the area of myofascial trigger points activated in a rat model by blunt ..." in: Journal of biomechanics, Vol. 66, pp. 44-50, (2019) (PubMed).
: "Attenuation of utero-toxicity, metabolic dysfunction and inflammation by soy protein concentrate in rats exposed to fluoridated water: consequence of hyperlipidemia in parallel with ..." in: Environmental science and pollution research international, Vol. 25, Issue 36, pp. 36462-36473, (2019) (PubMed).
: "Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 392, Issue 3, pp. 279-286, (2019) (PubMed).
: "Increased cerebral nuclear factor kappa B in a complex regional pain syndrome rat model: possible relationship between peripheral injury and the brain." in: Journal of pain research, Vol. 12, pp. 909-914, (2019) (PubMed).
Synonyms and alternative names related to NFkB
nuclear factor kappa B subunit 1 (NFKB1), nuclear factor kappa B subunit 1 (Nfkb1), nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (Nfkb1), EBP-1, KBF1, NF-kappa-B, NF-kappaB, NF-kappaB1, NF-kB, NF-kB1, NF-KB1, NFkappaB, NFKB-p50, NFKB-p105, p50, p50/p105, p105Protein level used designations for NFkB
- DNA binding factor KBF1
- DNA-binding factor KBF1
- NF-kappabeta
- nuclear factor NF-kappa-B p105 subunit
- nuclear factor NF-kappa-B p50 subunit
- nuclear factor kappa-B DNA binding subunit
- nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
- NF-kB p50 subunit
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
- nuclear factor kappa-B 1
- EBP-1
- NF kappaB1
- NF-kappa-B1 p84/NF-kappa-B1 p98
- NF-kappaB p50
- nuclear factor kappaB p50
- nuclear factor-kappaB p50
- p50 subunit of NF kappaB
- p50 subunit of NF-kappaB
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