NEDD4 Products
(Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))
Categories
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
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Featured NEDD4 Categories
NEDD4 Antibodies
High quality antibodies with extensive validation data.
NEDD4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NEDD4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN3031966
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN653889
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN1681009
Quantity
100 μg
Datasheet
Datasheet
Recommended NEDD4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6234773
Quantity
96 tests
Datasheet
Datasheet
Recommended NEDD4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312320
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094038
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134115
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NEDD4 products
: "H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis." in: Nature communications, Vol. 8, pp. 14799, (2017) (PubMed).: "p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN." in: Cell death and differentiation, Vol. 21, Issue 1, pp. 146-60, (2013) (PubMed).
: "Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25990-6, (2001) (PubMed).
: "All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+." in: The Journal of biological chemistry, Vol. 274, Issue 18, pp. 12525-30, (1999) (PubMed).
: "The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32329-36, (1998) (PubMed).
: "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases." in: The Journal of biological chemistry, Vol. 272, Issue 24, pp. 15085-92, (1997) (PubMed).
Synonyms and alternative names related to NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4), neural precursor cell expressed, developmentally down-regulated 4 (Nedd4), CG42279 gene product from transcript CG42279-RJ (Nedd4), E3 ubiquitin-protein ligase Nedd-4 (LOC411723), E3 ubiquitin-protein ligase NEDD4 (LOC100457150), neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (nedd4), E3 ubiquitin-protein ligase NEDD4 (LOC100547485), neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4), AA959633, AL023035, AU019897, CG7555, CG32184, CG42279, Dmel\\CG42279, Dmel_CG7555, Dmel_CG32184, DNedd4, dNedd4, dNedd4-1, E430025J12Rik, GB16853, mKIAA0093, nedd4, NEDD4, Nedd4, NEDD4-1, Nedd4-1, Nedd4a, RPF1Protein level used designations for NEDD4
- E3 ubiquitin-protein ligase NEDD4
- NEDD-4
- cell proliferation-inducing gene 53 protein
- neural precursor cell expressed developmentally down-regulated protein 4
- receptor-potentiating factor 1
- neural precursor cell expressed, developmentally down-regulated gene 4
- neural precursor cell expressed, developmentally down-regulated gene 4a
- neural precursor cell expressed, developmentally down-regulted gene 4
- CG42279-PE
- CG42279-PF
- CG42279-PG
- CG42279-PH
- CG42279-PI
- CG42279-PJ
- CG42279-PK
- CG42279-PL
- CG42279-PM
- DNedd4
- Nedd4-PE
- Nedd4-PF
- Nedd4-PG
- Nedd4-PH
- Nedd4-PI
- Nedd4-PJ
- Nedd4-PK
- Nedd4-PL
- Nedd4-PM
- neural precursor cell expressed, developmentally down-regulated 4
- ubiquitin-protein ligase Nedd4
- E3 ubiquitin-protein ligase NEDD4-like
- e3 ubiquitin-protein ligase NEDD4-like
- neural precursor cell expressed, developmentally down-regulated gene 4A
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