NEDD4-2 Products
(E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
Categories
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
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Featured NEDD4-2 Categories
NEDD4-2 Antibodies
High quality antibodies with extensive validation data.
NEDD4-2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NEDD4-2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IP
Validations
- (4)
Cat. No.
ABIN525093
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6144504
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (3)
Cat. No.
ABIN7264127
Quantity
200 μL
Datasheet
Datasheet
Recommended NEDD4-2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231540
Quantity
96 tests
Datasheet
Datasheet
Recommended NEDD4-2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312322
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312326
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136435
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NEDD4-2 products
: "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel." in: American journal of physiology. Renal physiology, Vol. 294, Issue 5, pp. F1157-65, (2008) (PubMed).Synonyms and alternative names related to NEDD4-2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L), NEDD4L (LOC776799), neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog (nedd4l.S), neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l), neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l), 1300012C07Rik, hNEDD4-2, nedd4, NEDD4, NEDD4-2, nedd4-2, Nedd4-2, NEDD4.2, Nedd4b, RSP5Protein level used designations for NEDD4-2
- E3 ubiquitin-protein ligase NEDD4-like
- E3 ubiquitin-protein ligase NEDD4-like protein
- ubiquitin-protein ligase Rsp5
- neural precursor cell expressed, developmentally down-regulated 4
- NEDD4.2
- neural precursor cell expressed, developmentally down-regulated gene 4b
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