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NBR1 Products

(Neighbor of BRCA1 Gene 1 (NBR1))

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The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

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Featured NBR1 Categories

NBR1 Antibodies

High quality antibodies with extensive validation data.

NBR1 ELISA Kits

Reliable ELISA kits for a wide range of species.

NBR1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NBR1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF, IP
Validations
  • (5)
Cat. No. ABIN1680974
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (4)
Cat. No. ABIN561705
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (7)
  • (2)
Cat. No. ABIN517601
Quantity 100 μg
Datasheet Datasheet

Recommended NBR1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968819
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6208870
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1145033
Quantity 96 tests
Datasheet Datasheet

Recommended NBR1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312051
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1780821
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094033
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our NBR1 products

Di Rienzo, Antonioli, Fusco, Liu, Mari, Orhon, Refolo, Germani, Corazzari, Romagnoli, Ciccosanti, Mandriani, Pellico, De La Torre, Ding, Dentice, Neri, Ferlini, Reggiori, Kulesz-Martin, Piacentini et al.: "Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. ..." in: Science advances, Vol. 5, Issue 5, pp. eaau8857, (2019) (PubMed).

Kim, Hwang, Cho, Chi, Park, Chang, Whang: "Depletion of NBR1 in urothelial carcinoma cells enhances rapamycin-induced apoptosis through impaired autophagy and mitochondrial dysfunction." in: Journal of cellular biochemistry, (2019) (PubMed).

Romagnoli, Petruccioli, Palucci, Camassa, Carata, Petrone, Mariano, Sali, Dini, Girardi, Delogu, Goletti, Fimia: "Clinical isolates of the modern Mycobacterium tuberculosis lineage 4 evade host defense in human macrophages through eluding IL-1β-induced autophagy." in: Cell death & disease, Vol. 9, Issue 6, pp. 624, (2018) (PubMed).

Kenific, Stehbens, Goldsmith, Leidal, Faure, Ye, Wittmann, Debnath: "NBR1 enables autophagy-dependent focal adhesion turnover." in: The Journal of cell biology, Vol. 212, Issue 5, pp. 577-90, (2016) (PubMed).

Jiang, Hara-Kuge, Yamashita, Fujiki: "Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 1, pp. 36-49, (2015) (PubMed).

Murrow, Malhotra, Debnath: "ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function." in: Nature cell biology, Vol. 17, Issue 3, pp. 300-10, (2015) (PubMed).

Malhotra, Warne, Salas, Xu, Debnath: "Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity." in: Autophagy, Vol. 11, Issue 1, pp. 145-54, (2015) (PubMed).

Dowdle, Nyfeler, Nagel, Elling, Liu, Triantafellow, Menon, Wang, Honda, Pardee, Cantwell, Luu, Cornella-Taracido, Harrington, Fekkes, Lei, Fang, Digan, Burdick, Powers, Helliwell, DAquin, Bastien et al.: "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. ..." in: Nature cell biology, Vol. 16, Issue 11, pp. 1069-79, (2014) (PubMed).

Rué, López-Soop, Gelpi, Martínez-Vicente, Alberch, Pérez-Navarro: "Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease." in: Neurobiology of disease, Vol. 52, pp. 219-28, (2013) (PubMed).

Deosaran, Larsen, Hua, Sargent, Wang, Kim, Lamark, Jauregui, Law, Lippincott-Schwartz, Brech, Johansen, Kim: "NBR1 acts as an autophagy receptor for peroxisomes." in: Journal of cell science, Vol. 126, Issue Pt 4, pp. 939-52, (2013) (PubMed).

Synonyms and alternative names related to NBR1

neighbor of brca1 gene 1a (nbr1a), neighbor of BRCA1 gene 1 L homeolog (nbr1.L), NBR1, autophagy cargo receptor (NBR1), neighbor of Brca1 gene 1 (Nbr1), NBR1, autophagy cargo receptor (Nbr1), 1A1-3B, Ca125, fa99f08, M17S2, MGC69008, mKIAA0049, NBR1, RGD1311421, wu:fa99f08

Protein level used designations for NBR1

  • neighbor of BRCA1 gene 1
  • next to BRCA1 gene 1 protein
  • next to BRCA1 gene 1 protein-like
  • cell migration-inducing gene 19 protein
  • membrane component chromosome 17 surface marker 2
  • membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)
  • migration-inducing protein 19
  • neighbor of BRCA1 gene 1 protein
  • protein 1A1-3B
  • membrane component chromosome 17 surface marker 2 homolog
  • next to the Brca1
  • ovarian carcinoma antigen CA125
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