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NANS Products

(N-Acetylneuraminic Acid Synthase (NANS))

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This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively\; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008].

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Featured NANS Categories

NANS Antibodies

High quality antibodies with extensive validation data.

NANS ELISA Kits

Reliable ELISA kits for a wide range of species.

NANS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NANS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7169549
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (3)
Cat. No. ABIN2856066
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN565721
Quantity 100 μg
Datasheet Datasheet

Recommended NANS ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958006
Quantity 96 tests
Datasheet Datasheet

Recommended NANS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124087
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311959
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311957
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our NANS products

van Karnebeek, Bonafé, Wen, Tarailo-Graovac, Balzano, Royer-Bertrand, Ashikov, Garavelli, Mammi, Turolla, Breen, Donnai, Cormier, Heron, Nishimura, Uchikawa, Campos-Xavier, Rossi, Hennet et al.: "NANS-mediated synthesis of sialic acid is required for brain and skeletal development. ..." in: Nature genetics, Vol. 48, Issue 7, pp. 777-84, (2016) (PubMed).

Synonyms and alternative names related to NANS

N-acetylneuraminate synthase L homeolog (nans.L), N-acetylneuraminate synthase (NANS), N-acetylneuraminate synthase (Nans), MGC84329, SAS

Protein level used designations for NANS

  • N-acetylneuraminic acid synthase
  • N-acetylneuraminic acid phosphate synthase
  • N-acetylneuraminic acid synthase (sialic acid synthase)
  • sialic acid synthase
  • N-acetylneuraminate synthase
  • N-acetylneuraminate-9-phosphate synthase
  • sialic acid phosphate synthase
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