NAGPA Products
(N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))
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Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008].
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Featured NAGPA Categories
NAGPA Antibodies
High quality antibodies with extensive validation data.
NAGPA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NAGPA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN7160684
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN565555
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7160687
Quantity
100 μg
Datasheet
Datasheet
Recommended NAGPA Proteins
Synonyms and alternative names related to NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA), N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAEGRDRAFT_56913), N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (Nagpa), AI596180, APAA, NAGPA, UCEProtein level used designations for NAGPA
- N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
- alpha-N-acetylglucosaminyl phosphodiesterase
- lysosomal alpha-N-acetylglucosaminidase
- mannose 6-phosphate-uncovering enzyme
- phosphodiester alpha-GlcNAcase
- alpha-GlcNAcase
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