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MYCN Products

(N-Myc Proto-Oncogene Protein (MYCN))

Categories

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq, Jul 2008].

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Featured MYCN Categories

MYCN Antibodies

High quality antibodies with extensive validation data.

MYCN ELISA Kits

Reliable ELISA kits for a wide range of species.

MYCN Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MYCN Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (3)
  • (1)
Cat. No. ABIN760676
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (1)
  • (6)
Cat. No. ABIN1680957
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS
Validations
  • (6)
Cat. No. ABIN7193585
Quantity 100 μL
Datasheet Datasheet

Recommended MYCN ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6974813
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5591497
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN2870005
Quantity 96 tests
Datasheet Datasheet

Recommended MYCN Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (4)
  • (1)
Cat. No. ABIN1311728
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124095
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311730
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our MYCN products

Cheng, He, Chen, Cai, Gu, Pan, Duan, Wu, Wu: "P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma." in: Molecular & cellular proteomics : MCP, Vol. 22, Issue 3, pp. 100504, (2023) (PubMed).

Murakami-Tonami, Ikeda, Yamagishi, Inayoshi, Inagaki, Kishida, Komata, Jan Koster, Takeuchi, Kondo, Maeda, Sekido, Murakami, Kadomatsu: "SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells." in: Scientific reports, Vol. 6, pp. 31615, (2016) (PubMed).

Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: "Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease." in: Oncotarget, Vol. 7, Issue 14, pp. 18605-19, (2016) (PubMed).

Chang, Yang, Zheng, Li, Nie: "Arsenic trioxide inhibits cancer stem-like cells via down-regulation of Gli1 in lung cancer." in: American journal of translational research, Vol. 8, Issue 2, pp. 1133-43, (2016) (PubMed).

Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: "p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma." in: Molecular cancer research : MCR, Vol. 13, Issue 3, pp. 584-91, (2015) (PubMed).

Smith, Moreno, Heaton, Chesler, Pearson, Garrett: "Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastoma." in: Molecular oncology, (2015) (PubMed).

Ruiz-Pérez, Medina, Urdiales, Keinänen, Sánchez-Jiménez: "Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells." in: The Journal of biological chemistry, Vol. 290, Issue 10, pp. 6106-19, (2015) (PubMed).

Yang, AlTahan, Hu, Wang, Cheng, Morton, Qu, Nathwani, Shohet, Fotsis, Koster, Versteeg, Okada, Harris, Davidoff: "The role of histone demethylase KDM4B in Myc signaling in neuroblastoma." in: Journal of the National Cancer Institute, Vol. 107, Issue 6, pp. djv080, (2015) (PubMed).

Suenaga, Islam, Alagu, Kaneko, Kato, Tanaka, Kawana, Hossain, Matsumoto, Yamamoto, Shoji, Itami, Shibata, Nakamura, Ohira, Haraguchi, Takatori, Nakagawara: "NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3? resulting in the stabilization of MYCN in human neuroblastomas." in: PLoS genetics, Vol. 10, Issue 1, pp. e1003996, (2014) (PubMed).

Murakami-Tonami, Kishida, Takeuchi, Katou, Maris, Ichikawa, Kondo, Sekido, Shirahige, Murakami, Kadomatsu: "Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells." in: Cell cycle (Georgetown, Tex.), Vol. 13, Issue 7, pp. 1115-31, (2014) (PubMed).

Synonyms and alternative names related to MYCN

MYCN proto-oncogene, bHLH transcription factor (MYCN), v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN), v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn), MYCN proto-oncogene, bHLH transcription factor (Mycn), olfactory receptor 8S1 (LOC515887), MYCN proto-oncogene, bHLH transcription factor (mycn), MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S), bHLHe37, c-nmyc, fb57a02, MODED, mycn, mycn-a, mycn-b, mycna, MYCNOT, N-myc, Nmuc1, NMYC, Nmyc, Nmyc-1, Nmyc1, nmyc1, ODED, wu:fb57a02, XN-myc, xN-myc1, XNmyc, zgc:85706

Protein level used designations for MYCN

  • N-myc proto-oncogene protein
  • class E basic helix-loop-helix protein 37
  • neuroblastoma MYC oncogene
  • neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
  • oncogene NMYC
  • pp65/67
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
  • N-myc protein
  • neuroblastoma myc-related oncogene 1
  • Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
  • Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
  • N-myc-like protein
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
  • MYCN proto-oncogene, bHLH transcription factor S homeolog
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a
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