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MUTYH Products

(MutY Homolog (E. Coli) (MUTYH))

Categories

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured MUTYH Categories

MUTYH Antibodies

High quality antibodies with extensive validation data.

MUTYH ELISA Kits

Reliable ELISA kits for a wide range of species.

MUTYH Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MUTYH Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IP, RNAi
Validations
  • (7)
  • (6)
Cat. No. ABIN561883
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p)
Validations
  • (5)
Cat. No. ABIN3187926
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF, ICC
Validations
  • (3)
Cat. No. ABIN6263442
Quantity 100 μL
Datasheet Datasheet

Recommended MUTYH ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957923
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1742632
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1773536
Quantity 96 tests
Datasheet Datasheet

Recommended MUTYH Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311668
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311667
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399868
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MUTYH products

Ferreira, Rosa Soares, Ramalho, Ribeiro-Rodrigues, Máximo, Zuzarte, Girão, Pereira: "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis." in: PLoS ONE, Vol. 14, Issue 10, pp. e0223790, (2020) (PubMed).

Zhang, Guo, Chen, Chen, Jin: "MUTYH and ORAI1 polymorphisms are associated with susceptibility to osteoarthritis in the Chinese Han population." in: The Journal of international medical research, Vol. 46, Issue 6, pp. 2292-2300, (2019) (PubMed).

Fang, Ohman Strickland, Kang, Zarbl: "Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis." in: Oncotarget, Vol. 8, Issue 20, pp. 32752-32768, (2017) (PubMed).

Komine, Shimodaira, Takao, Soeda, Zhang, Takahashi, Ishioka: "Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia Coli Strain." in: Human mutation, Vol. 36, Issue 7, pp. 704-11, (2015) (PubMed).

Shinmura, Goto, Tao, Kato, Suzuki, Nakamura, Matsuda, Yin, Morita, Kono, Sugimura: "Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer." in: Oxidative medicine and cellular longevity, Vol. 2014, pp. 617351, (2014) (PubMed).

Agustina, Hahm, Han, Tran, Chung, Park, Park, Han: "Visualization of the physical and functional interaction between hMYH and hRad9 by Dronpa bimolecular fluorescence complementation." in: BMC molecular biology, Vol. 15, pp. 17, (2014) (PubMed).

Turco, Ventura, Minoprio, Russo, Torreri, Degan, Molatore, Ranzani, Bignami, Mazzei: "Understanding the role of the Q338H MUTYH variant in oxidative damage repair." in: Nucleic acids research, Vol. 41, Issue 7, pp. 4093-103, (2013) (PubMed).

Raetz, Xie, Kundu, Brinkmeyer, Chang, David: "Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells." in: Carcinogenesis, Vol. 33, Issue 11, pp. 2301-9, (2012) (PubMed).

Hahm, Chung, Agustina, Han, Yoon, Park, Kang, Park, Na, Han: "Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells." in: Oncology letters, Vol. 4, Issue 6, pp. 1203-1208, (2012) (PubMed).

Zaika, Wei, Yin, Andl, Moll, El-Rifai, Zaika: "p73 protein regulates DNA damage repair." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 12, pp. 4406-14, (2011) (PubMed).

Synonyms and alternative names related to MUTYH

mutY DNA glycosylase (MUTYH), mutY homolog (E. coli) (MUTYH), mutY DNA glycosylase (mutyh), A/G-specific adenine DNA glycosylase-like (LOC100373318), mutY DNA glycosylase (Mutyh), 5730495A01Rik, CYP2C, MGC145569, MUTYH, Mutyha, Mutyhalpha, Mutyhb, Mutyhbeta, Mutyhc, MYH, Myh

Protein level used designations for MUTYH

  • mutY homolog (E. coli)
  • A/G-specific adenine DNA glycosylase
  • A/G-specific adenine DNA glycosylase-like
  • mutY homolog
  • adenine-DNA glycosylase
  • mMYH
  • mutY homolog alpha
  • the full-length form type A, 5' region
  • rMYH
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