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MTHFR Products

(Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

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The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009].

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Featured MTHFR Categories

MTHFR Antibodies

High quality antibodies with extensive validation data.

MTHFR ELISA Kits

Reliable ELISA kits for a wide range of species.

MTHFR Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MTHFR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (9)
Cat. No. ABIN7436504
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
  • (5)
Cat. No. ABIN969297
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7159642
Quantity 100 μg
Datasheet Datasheet

Recommended MTHFR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957798
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6230640
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1142379
Quantity 96 tests
Datasheet Datasheet

Recommended MTHFR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311562
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7399403
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3084059
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MTHFR products

Khot, Yadav, Shrestha, Kaur, Sundrani, Chavan-Gautam, Mehendale, Chandak, Joshi: "Hypermethylated CpG sites in the MTR gene promoter in preterm placenta." in: Epigenomics, Vol. 9, Issue 7, pp. 985-996, (2018) (PubMed).

Genovese, Gualandi, Taddia, Marverti, Pirondi, Marraccini, Perco, Pelà, Guerrini, Amoroso, Esposito, Martello, Ponterini, DArca, Costi: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).

Forges, Chery, Audonnet, Feillet, Gueant: "Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: characterization of two novel mutations in compound heterozygous patients." in: Molecular genetics and metabolism, Vol. 100, Issue 2, pp. 143-8, (2010) (PubMed).

Sonne: "WITHDRAWN: Health effects from long-range transported contaminants in Arctic top predators: An integrated review based on studies of polar bears and relevant model species." in: Environment international, (2010) (PubMed).

Singh, Singh, Raman: "MTHFR A1298C polymorphism and idiopathic male infertility." in: Journal of postgraduate medicine, Vol. 56, Issue 4, pp. 267-9, (2010) (PubMed).

Harisha, Devi, Christopher, Kruthika-Vinod: "Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects." in: Journal of neurosurgery. Pediatrics, Vol. 6, Issue 4, pp. 364-7, (2010) (PubMed).

Wu, Chang, Tsai, Lin, Wang, Tsai, Chen, Yao, Chiu, Bau, Lin: "Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan." in: Anticancer research, Vol. 30, Issue 9, pp. 3573-7, (2010) (PubMed).

Magnowski, Seremak-Mrozikiewicz, Nowak-Markwitz, Kurzawińska, Drews, Spaczyński: "[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region]." in: Ginekologia polska, Vol. 81, Issue 7, pp. 506-10, (2010) (PubMed).

Kristensen, Pedersen, Melsen, Ellehauge, Mejer: "Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients." in: The Journal of international medical research, Vol. 38, Issue 3, pp. 870-83, (2010) (PubMed).

Sarecka-Hujar, Zak, Krauze: "Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease." in: Kardiologia polska, Vol. 66, Issue 12, pp. 1269-77, (2009) (PubMed).

Synonyms and alternative names related to MTHFR

methylenetetrahydrofolate reductase (NAD(P)H) L homeolog (mthfr.L), methylenetetrahydrofolate reductase (MTHFR), methylenetetrahydrofolate reductase (NAD(P)H) (mthfr), methylenetetrahydrofolate reductase (metF), methylenetetrahydrofolate reductase (DDB_G0279137), 5,10-methylenetetrahydrofolate reductase (Mthfr), methylenetetrahydrofolate reductase (Mthfr), AI323986, DDBDRAFT_0204686, DDBDRAFT_0230137, DDB_0204686, DDB_0230137

Protein level used designations for MTHFR

  • 5,10-methylenetetrahydrofolate reductase
  • 5,10-methylenetetrahydrofolate reductase (NADPH)
  • methylenetetrahydrofolate reductase (NAD(P)H)
  • methylenetetrahydrofolate reductase-like
  • methylenetetrahydrofolate reductase
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