MTA1 Products
(Metastasis Associated 1 (MTA1))
Categories
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
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Featured MTA1 Categories
MTA1 Antibodies
High quality antibodies with extensive validation data.
MTA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MTA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (7)
Cat. No.
ABIN522561
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (6)
Cat. No.
ABIN563943
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN7193370
Quantity
100 μL
Datasheet
Datasheet
Recommended MTA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957781
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648083
Quantity
96 tests
Datasheet
Datasheet
Recommended MTA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311515
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311513
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311512
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our MTA1 products
: "Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function." in: The Journal of biological chemistry, Vol. 287, Issue 33, pp. 27843-50, (2012) (PubMed).: "MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response." in: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7132-8, (2011) (PubMed).
: "TGF-β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells." in: Oncogene, Vol. 30, Issue 19, pp. 2230-41, (2011) (PubMed).
: "Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1159-66, (2010) (PubMed).
: "Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells." in: Molecular and cellular biology, Vol. 30, Issue 16, pp. 4045-59, (2010) (PubMed).
: "[Expression of Mta-1 and VEGF and their correlation in the endometrial cancer]." in: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, Vol. 26, Issue 7, pp. 682-4, (2010) (PubMed).
: "Requirement of MTA1 in ATR-mediated DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 19802-12, (2010) (PubMed).
: "Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 10044-52, (2010) (PubMed).
: "MTA1 coregulator regulates LPS response via MyD88-dependent signaling." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 32787-92, (2010) (PubMed).
: "MTA1 coregulator regulates p53 stability and function." in: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 34545-52, (2009) (PubMed).
Synonyms and alternative names related to MTA1
metastasis associated 1 (MTA1), metastasis associated 1 (Mta1), metastasis associated 1 L homeolog (mta1.L), Tex22Protein level used designations for MTA1
- metastasis associated gene 1 protein
- metastasis-associated protein MTA1
- testis expressed 22
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